3-Hydroxythiophene-2-carboxylic acid
- Product Name
- 3-Hydroxythiophene-2-carboxylic acid
- CAS No.
- 5118-07-0
- Chemical Name
- 3-Hydroxythiophene-2-carboxylic acid
- Synonyms
- 3-Hydroxy-2-thiophenecarboxylic acid;3-Hydroxythiophene-2-carboxylic acid;2-Thiophenecarboxylic acid, 3-hydroxy-;2-(dihydroxymethylidene)-3-thiophenone;3-Hydroxythiophene-2-carboxylic acid 97%;2-Carboxy-3-hydroxythiophene, 3-Hydroxy-2-thenoic acid;3-Hydroxythiophene-2-carboxylic acid ISO 9001：2015 REACH
- CBNumber
- CB9956788
- Molecular Formula
- C5H4O3S
- Formula Weight
- 144.15
- MOL File
- 5118-07-0.mol
3-Hydroxythiophene-2-carboxylic acid Property
- Melting point:
- 108 °C(Solv: acetone (67-64-1))
- Boiling point:
- 326.4±27.0 °C(Predicted)
- Density
- 1.603±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- form
- crystalline powder
- pka
- 3.79±0.10(Predicted)
- color
- Brown/grey
Safety
- Hazard Codes
- Xi
- HS Code
- 2934999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- H963570
- Product name
- 3-Hydroxythiophene-2-carboxylicAcid
- Packaging
- 100mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- H963570
- Product name
- 3-Hydroxythiophene-2-carboxylicAcid
- Packaging
- 500mg
- Price
- $695
- Updated
- 2021/12/16
- Product number
- 6H66-1-X2
- Product name
- 3-Hydroxythiophene-2-carboxylic acid
- Purity
- 97%
- Packaging
- 250mg
- Price
- $205
- Updated
- 2021/12/16
- Product number
- 7114AB
- Product name
- 3-Hydroxythiophene-2-carboxylicacid
- Packaging
- 250mg
- Price
- $236
- Updated
- 2021/12/16
- Product number
- 082513
- Product name
- 3-Hydroxythiophene-2-carboxylic acid
- Purity
- 97%
- Packaging
- 1g
- Price
- $470
- Updated
- 2021/12/16
3-Hydroxythiophene-2-carboxylic acid Chemical Properties,Usage,Production
Uses
3-Hydroxythiophene-2-carboxylic acid (cas# 5118-07-0) is a useful research chemical. This compound is useful because furoates and thenoates inhibit pyruvate dehydrogenase kinase 2 allosterically by binding to its pyruvate regulatory site.
Synthesis
186588-88-5
5118-07-0
General procedure for the synthesis of 3-hydroxythiophene-2-carboxylic acid from 3-benzyloxythiophene-2-carboxylic acid: a) 3-benzyloxythiophene-2-carboxylic acid (1.0 g) was hydrogenated with 10% palladium-carbon catalyst (1.8 g) in a mixture of ethanol (150 mL) and 2N hydrochloric acid (4.5 mL) for 2 hours at 45 psi hydrogen pressure. Upon completion of the reaction, the mixture was filtered through a layer of diatomaceous earth and the filtrate was concentrated under vacuum to afford 3-hydroxythiophene-2-carboxylic acid (600 mg, 98% yield) as an off-white solid product. The product was characterized by 1H NMR (300 MHz, CDCl3): δ 6.78 (d, 1H), 7.49 (d, 1H). Mass spectrometry (APCI) showed m/z=145 (M+1).LC/MS analysis showed a retention time of 1.15 min.
References
[1] Patent: WO2007/1225, 2007, A1. Location in patent: Page/Page column 16
3-Hydroxythiophene-2-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
3-Hydroxythiophene-2-carboxylic acid Suppliers
- Tel
- --
- Fax
- --
- chemcontrol@nextra.sk
- Country
- Slovakia
- ProdList
- 6700
- Advantage
- 60
View Lastest Price from 3-Hydroxythiophene-2-carboxylic acid manufacturers
- Product
- 3-Hydroxythiophene-2-carboxylic acid 5118-07-0
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-13