6-Fluoropyridine-2-boronic acid
- Product Name
- 6-Fluoropyridine-2-boronic acid
- CAS No.
- 916176-61-9
- Chemical Name
- 6-Fluoropyridine-2-boronic acid
- Synonyms
- 6-Fluorpyridine-2-boronic acid;6-Fluoro-2-pyridineboronic acid;(6-fluoropyridin-2-yl)boronicaci;6-Fluoropyridin-2-ylboronic acid;(6-Fluoro-2-pyridyl)boronic acid;B-(6-Fluoro-2-pyridinyl)-boronic acid;Boronic acid, B-(6-fluoro-2-pyridinyl)-;6-Fluoropyridine-2-boronic acid ISO 9001：2015 REACH
- CBNumber
- CB9967546
- Molecular Formula
- C5H5BFNO2
- Formula Weight
- 140.91
- MOL File
- 916176-61-9.mol
6-Fluoropyridine-2-boronic acid Property
- Boiling point:
- 327℃
- Density
- 1.34
- Flash point:
- 152℃
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- pka
- 6.76±0.53(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C5H5BFNO2/c7-5-3-1-2-4(8-5)6(9)10/h1-3,9-10H
- InChIKey
- KUKRPJYXNBIBIT-UHFFFAOYSA-N
- SMILES
- B(C1=NC(F)=CC=C1)(O)O
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- F596198
- Product name
- 6-Fluoropyridine-2-boronicacid
- Packaging
- 250mg
- Price
- $70
- Updated
- 2021/12/16
- Product number
- PC412475
- Product name
- 6-Fluoropyridine-2-boronicacid
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- 132012
- Product name
- 6-Fluoropyridin-2-ylboronicacid
- Purity
- 97%
- Packaging
- 1g
- Price
- $964
- Updated
- 2021/12/16
- Product number
- BOR0002273
- Product name
- 6-FLUOROPYRIDINE-2-BORONIC ACID
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $970.2
- Updated
- 2021/12/16
- Product number
- V9108
- Product name
- 6-Fluoropyridine-2-boronicacid
- Packaging
- 5g
- Price
- $1051
- Updated
- 2021/12/16
6-Fluoropyridine-2-boronic acid Chemical Properties,Usage,Production
Synthesis
144100-07-2
916176-61-9
Under nitrogen protection, 2-bromo-6-fluoropyridine (2.5 g, 14.2 mmol, 1 eq.) and triisopropyl borate (4 mL) were dissolved in a solvent mixture of toluene (50 mL) and tetrahydrofuran (12.5 mL) and the reaction system was cooled to -78 °C. n-Butyllithium (10.8 mL, 1.6 M hexane solution) was slowly added dropwise over 1.25 hours. After the dropwise addition was completed, the reaction mixture was stirred at -78 °C for 30 min, followed by slow warming to 0 °C over 2 h. Upon completion of the reaction, the reaction was quenched with 2M aqueous hydrochloric acid solution (10 mL) and stirred at room temperature for 1 hour. The organic phase was separated, washed with 0.5 M aqueous hydrochloric acid, dried over anhydrous sodium sulfate and concentrated under a stream of nitrogen to remove the solvent. The aqueous phase was neutralized with saturated sodium bicarbonate solution and extracted with ethyl acetate, the organic phases were combined, dried over anhydrous sodium sulfate and concentrated under a stream of nitrogen to give the second product. Final isolation afforded 2-fluoropyridine-6-boronic acid as a white solid (1.27 g, 64% yield).
References
[1] Patent: WO2006/127587, 2006, A1. Location in patent: Page/Page column 95-96
6-Fluoropyridine-2-boronic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-Fluoropyridine-2-boronic acid manufacturers
- Product
- 6-Fluoropyridine-2-boronic acid 916176-61-9
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-10-19
- Product
- 6-Fluoropyridine-2-boronic acid 916176-61-9
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1ton
- Release date
- 2019-07-11