6-FLUOROPYRIDINE-2-BORONIC ACID PINACOL ESTER

Product Name: 6-FLUOROPYRIDINE-2-BORONIC ACID PINACOL ESTER
CAS No.: 842136-58-7
Chemical Name: 6-FLUOROPYRIDINE-2-BORONIC ACID PINACOL ESTER
Synonyms: 6-FLUOROPYRIDINE-2-BORONIC ACID PINACOL ESTER;6-Fluoropyridine-2-boronic acid pionacol ester;2-Fluoro-pyridine-6-boronic acid pinacol ester;6-Fluoropyridine-2-boronic acid poinacol ester;2-fluoro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine;Pyridine,2-fluoro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-;2-Fluoro-6-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine - [F87516]
CBNumber: CB3122565
Molecular Formula: C11H15BFNO2
Formula Weight: 223.05
MOL File: 842136-58-7.mol

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6-FLUOROPYRIDINE-2-BORONIC ACID PINACOL ESTER Property

Density: 1.09
storage temp.: Inert atmosphere,Store in freezer, under -20°C
InChI: InChI=1S/C11H15BFNO2/c1-10(2)11(3,4)16-12(15-10)8-6-5-7-9(13)14-8/h5-7H,1-4H3
InChIKey: WGPVNHXZZUGSMO-UHFFFAOYSA-N
SMILES: C1C=CC(B2OC(C)(C)C(C)(C)O2)=NC=1F

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: F596238
Product name: 6-Fluoropyridine-2-boronicacidpinacolester
Packaging: 50mg
Price: $100
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: BOR0004109
Product name: 2-FLUORO-6-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-PYRIDINE
Purity: 95.00%
Packaging: 1G
Price: $574.35
Updated: 2021/12/16

AK Scientific

Product number: Y4176
Product name: 2-Fluoro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
Packaging: 5g
Price: $1651
Updated: 2021/12/16

Crysdot

Product number: CD11048258
Product name: 2-Fluoro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
Purity: 95+%
Packaging: 100mg
Price: $89
Updated: 2021/12/16

Chemenu

Product number: CM128929
Product name: 2-Fluoro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
Purity: 96%
Packaging: 250mg
Price: $130
Updated: 2021/12/16

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6-FLUOROPYRIDINE-2-BORONIC ACID PINACOL ESTER Chemical Properties,Usage,Production

Synthesis

144100-07-2

73183-34-3

842136-58-7

General procedure for the synthesis of 6-fluoro-2-pyridineboronic acid pinacol ester from 2-bromo-6-fluoropyridine and bis(pinacolato)diboron as raw materials: under nitrogen protection, Pd(dppf)2Cl2-CH2Cl2 (102 mg, 0.14 mmol) was added to a degassed 2-bromo-6-fluoropyridine (410 mg, 2.33 mmol), bis(pinacolato)diboron ( 828 mg, 3.26 mmol) and KOAc (685 mg, 6.99 mmol) in a solution of dioxane (6 mL). The reaction mixture was heated with stirring at 115 °C for 1 hour. After completion of the reaction, it was cooled to room temperature and the solvent was removed by distillation under reduced pressure. The residue was purified by silica gel column chromatography (eluent: dichloromethane/methanol, 100:0 to 90:10), and the fraction containing the target product was collected and concentrated under reduced pressure to give pinacol ester of 6-fluoro-2-pyridineboronic acid (400 mg, 76% yield). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 7.78 (td, J = 8.1, 7.2 Hz, 1H), 7.70 (ddd, J = 6.9, 2.8, 0.9 Hz, 1H), 6.98 (ddd, J = 8.1, 2.7, 0.9 Hz, 1H), 1.38 (s, 12H).

References

[1] Patent: US2014/275120, 2014, A1. Location in patent: Paragraph 0531; 0532
[2] Patent: US2009/203705, 2009, A1. Location in patent: Page/Page column 43
[3] Patent: WO2012/101063, 2012, A1. Location in patent: Page/Page column 143-144
[4] Patent: WO2012/101064, 2012, A1. Location in patent: Page/Page column 185
[5] Patent: WO2014/139328, 2014, A1. Location in patent: Page/Page column 403

6-FLUOROPYRIDINE-2-BORONIC ACID PINACOL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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6-FLUOROPYRIDINE-2-BORONIC ACID PINACOL ESTER Suppliers

China 43 India 2 United States 7 Global 52

Hangzhou Milestone Pharmtech Co., Ltd.

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842136-58-7, 6-FLUOROPYRIDINE-2-BORONIC ACID PINACOL ESTERRelated Search:

1-METHYL-4-[5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABORALAN-2-YL)PYRIDINE-2-YL]PIPERAZINE N-(4-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)acetaMide 2-CYANOPYRIDINE-4-BORONIC ACID PINACOL ESTER 1-(5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDIN-2-YL)PIPERAZINE 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)chroman, 97% 6-Fluoropyridine-2-boronic acid 6-FLUOROPYRIDINE-2-BORONIC ACID PINACOL ESTER

6-FLUOROPYRIDINE-2-BORONIC ACID PINACOL ESTER

6-Fluoropyridine-2-boronic acid pionacol ester

2-fluoro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

Pyridine,2-fluoro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-

6-Fluoropyridine-2-boronic acid poinacol ester

2-Fluoro-pyridine-6-boronic acid pinacol ester

2-Fluoro-6-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine - [F87516]

842136-58-7