N-(4-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)acetaMide

Product Name: N-(4-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)acetaMide
CAS No.: 1220220-21-2
Chemical Name: N-(4-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)acetaMide
Synonyms: 184572;2-acetyl aminopyridine-4-phenool borate;(2-acetamidopyridin-4-yl)boronic acid pinacol ester;N-[4-(tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-2- yl]acetaMide;N-(4-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)acetaMide;Acetamide, N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl]-;N-(4-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)acetaMide ISO 9001：2015 REACH
CBNumber: CB32550384
Molecular Formula: C13H19BN2O3
Formula Weight: 262.11
MOL File: 1220220-21-2.mol

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N-(4-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)acetaMide Property

Boiling point:: 451.8±30.0 °C(Predicted)
Density: 1.11±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 13.92±0.70(Predicted)
Appearance: Off-white to gray Solid
InChI: InChI=1S/C13H19BN2O3/c1-9(17)16-11-8-10(6-7-15-11)14-18-12(2,3)13(4,5)19-14/h6-8H,1-5H3,(H,15,16,17)
InChIKey: LXSZMGQQXZXQKX-UHFFFAOYSA-N
SMILES: C(NC1=NC=CC(B2OC(C)(C)C(C)(C)O2)=C1)(=O)C

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-D1265
Product name: N-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]acetamide
Purity: >97.0%
Packaging: 250mg
Price: $53
Updated: 2021/12/16

ChemScene

Product number: CS-D1265
Product name: N-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]acetamide
Purity: >97.0%
Packaging: 1g
Price: $159
Updated: 2021/12/16

AK Scientific

Product number: 4189AA
Product name: N-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)acetamide
Packaging: 1g
Price: $251
Updated: 2021/12/16

ChemScene

Product number: CS-D1265
Product name: N-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]acetamide
Purity: >97.0%
Packaging: 5g
Price: $509
Updated: 2021/12/16

AK Scientific

Product number: 4189AA
Product name: N-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)acetamide
Packaging: 5g
Price: $651
Updated: 2021/12/16

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N-(4-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)acetaMide Chemical Properties,Usage,Production

Synthesis

1026796-81-5

73183-34-3

1220220-21-2

GENERAL STEPS: To a 1L four-necked flask equipped with a magnetic stirrer, thermometer, reflux condenser and bubbler was added 55.91 g (0.26 mol) of N-(4-bromo-pyridin-2-yl)acetamide and 66.02 g (0.26 mol) of bis(boronic acid) pinacol ester, followed by 76.44 g (0.78 mol) of potassium acetate and 450 mL of dioxane, and mixed by stirring. Under nitrogen protection, 3.81 g (0.0051 mol) of palladium dichlorodichalcogenide was added and the reaction was warmed to 100 °C for 18 to 24 h. The progress of the reaction was monitored by thin layer chromatography (TLC). Upon completion of the reaction, it was cooled to room temperature, precipitated as a solid, pulped and filtered. The filtrate was dissolved in 500 mL of methanol, filtered again, and the filtrate evaporated to dryness. Finally, heptane was added for pulping to obtain 62.08 g of the target product 2-acetylaminopyridine-4-boronic acid pinacol ester in 91.1% yield.

References

[1] Patent: CN103601745, 2017, B. Location in patent: Paragraph 0025; 0026
[2] Angewandte Chemie - International Edition, 2016, vol. 55, # 36, p. 10890 - 10894
[3] Angew. Chem., 2016, vol. 128, p. 11050 - 11054,5
[4] Journal of Medicinal Chemistry, 2017, vol. 60, # 13, p. 5613 - 5637
[5] Patent: US2013/165464, 2013, A1. Location in patent: Paragraph 0835

N-(4-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)acetaMide Preparation Products And Raw materials

Raw materials

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N-(4-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)acetaMide Suppliers

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View Lastest Price from N-(4-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)acetaMide manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: N-(4-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)acetaMide 1220220-21-2
Price: US $1.10/g
Min. Order: 1g
Purity: 99.0% min
Supply Ability: 100 tons min
Release date: 2021-05-12

Zhuozhou Wenxi import and Export Co., Ltd

Product: N-(4-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)acetaMide 1220220-21-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: N-(4-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)acetaMide 1220220-21-2
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

1220220-21-2, N-(4-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)acetaMideRelated Search:

Cyclopropanecarboxylic acid [4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridin-2-yl]-amide 1-METHYL-4-[5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABORALAN-2-YL)PYRIDINE-2-YL]PIPERAZINE 2-CYANOPYRIDINE-4-BORONIC ACID PINACOL ESTER 6-FLUOROPYRIDINE-2-BORONIC ACID PINACOL ESTER 1-(5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDIN-2-YL)PIPERAZINE 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)chroman, 97%

N-(4-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)acetaMide

N-[4-(tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-2- yl]acetaMide

184572

Acetamide, N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinyl]-

(2-acetamidopyridin-4-yl)boronic acid pinacol ester

N-(4-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl)acetaMide ISO 9001：2015 REACH

2-acetyl aminopyridine-4-phenool borate

1220220-21-2