ChemicalBook > CAS DataBase List > S(-)-8-HYDROXY-DPAT HYDROBROMIDE PARTIAL 5-HT1A SECROT

S(-)-8-HYDROXY-DPAT HYDROBROMIDE PARTIAL 5-HT1A SECROT

Product Name
S(-)-8-HYDROXY-DPAT HYDROBROMIDE PARTIAL 5-HT1A SECROT
CAS No.
78950-78-4
Chemical Name
S(-)-8-HYDROXY-DPAT HYDROBROMIDE PARTIAL 5-HT1A SECROT
Synonyms
3-(dipropylamino)tetralin-5-ol;7-(dipropylamino)tetralin-1-ol;2-(Dipropylamino)tetralin-8-ol;8-OH-DPAT (8-Hydroxy-DPAT) ，S8447;8-Hydroxy-2-(di-n-propylamino)tetralin;S(-)-8-Hydroxy-DPAT hydrobromide solid;7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol;5,6,7,8-Tetrahydro-7-(dipropylamino)naphthalen-1-ol;(+/-)-8-Hydroxy-2-dipropylaminotetralinehydrobromide;1-Naphthalenol,7-(dipropylamino)-5,6,7,8-tetrahydro-
CBNumber
CB9972175
Molecular Formula
C16H25NO
Formula Weight
247.38
MOL File
78950-78-4.mol
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S(-)-8-HYDROXY-DPAT HYDROBROMIDE PARTIAL 5-HT1A SECROT Property

Boiling point:
372.5±42.0 °C(Predicted)
Density 
1.03±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
150mg/ml in DMSO
form 
solid
pka
10.54±0.40(Predicted)
color 
white
optical activity
[α]25/D 67.8° in methanol(lit.)
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Safety

Safety Statements 
22-24/25
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
H141
Product name
S(?)-8-Hydroxy-DPAT hydrobromide
Purity
solid
Packaging
5mg
Price
$129
Updated
2022/05/15
Sigma-Aldrich
Product number
H141
Product name
S(?)-8-Hydroxy-DPAT hydrobromide
Purity
solid
Packaging
25mg
Price
$426
Updated
2022/05/15
Sigma-Aldrich
Product number
H141
Product name
S(?)-8-Hydroxy-DPAT hydrobromide
Purity
solid
Packaging
100mg
Price
$1430
Updated
2022/05/15
TRC
Product number
O415005
Product name
8-OH-DPAT
Packaging
100mg
Price
$1200
Updated
2021/12/16
ChemScene
Product number
CS-0043224
Product name
8-OH-DPAT
Purity
≥98.0%
Packaging
5mg
Price
$50
Updated
2021/12/16
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S(-)-8-HYDROXY-DPAT HYDROBROMIDE PARTIAL 5-HT1A SECROT Chemical Properties,Usage,Production

Uses

8-OH-DPAT, is a potent and selective 5-HT agonist.

Definition

ChEBI: A tetralin substituted at positions 1 and 7 by hydroxy and dipropylamino groups respectively

Hazard

A poison.

Biochem/physiol Actions

Partial 5-HT1A serotonin receptor agonist.

in vivo

8-OH-DPAT (1 mg/kg) normalizes hypolocomotion, significantly increases wakefulness and reduces the duration of REM sleep without effect on the duration of non-REM sleep in the dark period in orexin knockout (KO) mice. 8-OH-DPAT shows no obvious effect on wakefulness or the duration of either REM sleep or non-REM sleep in WT mice. 8-OH-DPAT (1 mg/kg, s.c.) activates 5-HT1A receptor in orexin knockout mice[3].

IC 50

5-HT1A Receptor: 8.19 (pIC50); 5-HT7 Receptor: 466 nM (Ki)

S(-)-8-HYDROXY-DPAT HYDROBROMIDE PARTIAL 5-HT1A SECROT Preparation Products And Raw materials

Raw materials

Preparation Products

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S(-)-8-HYDROXY-DPAT HYDROBROMIDE PARTIAL 5-HT1A SECROT Suppliers

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78950-78-4, S(-)-8-HYDROXY-DPAT HYDROBROMIDE PARTIAL 5-HT1A SECROTRelated Search:

8-HYDROXY-DPAT HYDROBROMIDE

  • S(-)-8-HYDROXY-DPAT HYDROBROMIDE PARTIAL 5-HT1A SECROT
  • (+/-)-8-Hydroxy-2-dipropylaminotetralinehydrobromide
  • 7-(dipropylamino)tetralin-1-ol
  • 8-Hydroxy-2-(di-n-propylamino)tetralin
  • 2-(Dipropylamino)tetralin-8-ol
  • 2-(N,N-Dipropylamino)-1,2,3,4-tetrahydronaphthalen-8-ol
  • 5,6,7,8-Tetrahydro-7-(dipropylamino)naphthalen-1-ol
  • 8-Hydroxy-2-(dipropylamino)-1,2,3,4-tetrahydronaphthalene
  • 3-(dipropylamino)tetralin-5-ol
  • 7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol
  • S(-)-8-Hydroxy-DPAT hydrobromide solid
  • 1-Naphthalenol,7-(dipropylamino)-5,6,7,8-tetrahydro-
  • 8-OH-DPAT (8-Hydroxy-DPAT) ，S8447
  • 78950-78-4
  • Serotonin receptor