CPNQ

Product Name: CPNQ
CAS No.: 115687-05-3
Chemical Name: CPNQ
Synonyms: B2;CPNQ;SIRT2-IN-8;SIRT2 Inhibitor, B2;Linazolamide intermediate B impurity 2;5-[4-(4-Chlorobenzoyl)-1-piperazinyl]-8-nitroquinoline;(4-chlorophenyl)-[4-(8-nitroquinolin-5-yl)piperazin-1-yl]methanone;Methanone, (4-chlorophenyl)[4-(8-nitro-5-quinolinyl)-1-piperazinyl]-;Sirtuin,Parkinson’s diseases,Huntington’s diseases,Inhibitor,B2,inhibit,B-2
CBNumber: CB9972382
Molecular Formula: C20H17ClN4O3
Formula Weight: 396.83
MOL File: 115687-05-3.mol

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CPNQ Property

Melting point:: 174-176°C
Boiling point:: 645.5±55.0 °C(Predicted)
Density: 1.412±0.06 g/cm3(Predicted)
storage temp.: Store at +4°C
solubility: H2O: insoluble <2mg/mL
pka: 2.30±0.29(Predicted)
form: solid
color: brown

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Safety

Hazard Codes: T
Risk Statements: 25-36/37/38
Safety Statements: 26-45
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: C3118
Product name: CPNQ
Purity: ≥98% (HPLC), solid
Packaging: 5mg
Price: $193
Updated: 2024/03/01

Sigma-Aldrich

Product number: C3118
Product name: CPNQ
Purity: ≥98% (HPLC), solid
Packaging: 25mg
Price: $719
Updated: 2021/12/16

TRC

Product number: B820015
Product name: B2
Packaging: 1mg
Price: $200
Updated: 2021/12/16

Usbiological

Product number: 254701
Product name: B2
Packaging: 10mg
Price: $403
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0008461
Product name: CPNQ
Purity: 95.00%
Packaging: 10MG
Price: $673.08
Updated: 2021/12/16

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CPNQ Chemical Properties,Usage,Production

Uses

B2 is a cell permeable inhibitor of SIRT2 (sirtuin 2). Multidrug resistance protein 4 (MRP4) inhibitor in tumors such as neuroblastoma and colorectal cancer.

Definition

ChEBI: (4-chlorophenyl)-[4-(8-nitro-5-quinolinyl)-1-piperazinyl]methanone is a N-arylpiperazine.

Biological Activity

Promotes inclusion formation in cellular models of Huntington's disease and Parkinson's disease. Prevents huntingtin-mediated proteasome dysfunction and reduces α -synuclein-mediated toxicity.

CPNQ Preparation Products And Raw materials

Raw materials

Preparation Products

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CPNQ Suppliers

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115687-05-3, CPNQRelated Search:

Oseltamivir phosphate 1-[4-(4-AMINO-PHENYL)-PIPERAZIN-1-YL]-ETHANONE CPNQ 4-(4-BENZYLPIPERAZINO)ANILINE 1-BENZYL-4-(4-NITROPHENYL)PIPERAZINE (4-CHLOROPHENYL)(PIPERAZIN-1-YL) METHANONE 1-Acetyl-4-(4-nitrophenyl)piperazine 1-(4-Nitrophenyl)piperazine

5-[4-(4-Chlorobenzoyl)-1-piperazinyl]-8-nitroquinoline

B2

Linazolamide intermediate B impurity 2

(4-chlorophenyl)-[4-(8-nitroquinolin-5-yl)piperazin-1-yl]methanone

SIRT2 Inhibitor, B2

Methanone, (4-chlorophenyl)[4-(8-nitro-5-quinolinyl)-1-piperazinyl]-

Sirtuin,Parkinson’s diseases,Huntington’s diseases,Inhibitor,B2,inhibit,B-2

SIRT2-IN-8

CPNQ

115687-05-3