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CPNQ

Product Name
CPNQ
CAS No.
115687-05-3
Chemical Name
CPNQ
Synonyms
B2;CPNQ;SIRT2-IN-8;SIRT2 Inhibitor, B2;Linazolamide intermediate B impurity 2;5-[4-(4-Chlorobenzoyl)-1-piperazinyl]-8-nitroquinoline;(4-chlorophenyl)-[4-(8-nitroquinolin-5-yl)piperazin-1-yl]methanone;Methanone, (4-chlorophenyl)[4-(8-nitro-5-quinolinyl)-1-piperazinyl]-;Sirtuin,Parkinson’s diseases,Huntington’s diseases,Inhibitor,B2,inhibit,B-2
CBNumber
CB9972382
Molecular Formula
C20H17ClN4O3
Formula Weight
396.83
MOL File
115687-05-3.mol
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CPNQ Property

Melting point:
174-176°C
Boiling point:
645.5±55.0 °C(Predicted)
Density 
1.412±0.06 g/cm3(Predicted)
storage temp. 
Store at +4°C
solubility 
H2O: insoluble <2mg/mL
pka
2.30±0.29(Predicted)
form 
solid
color 
brown
Water Solubility 
H2O: insoluble <2mg/mL
DMSO: >5mg/mL
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Safety

Hazard Codes 
T
Risk Statements 
25-36/37/38
Safety Statements 
26-45
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C3118
Product name
CPNQ
Purity
≥98% (HPLC), solid
Packaging
5mg
Price
$168
Updated
2025/07/31
Sigma-Aldrich
Product number
C3118
Product name
CPNQ
Purity
≥98% (HPLC), solid
Packaging
25mg
Price
$719
Updated
2021/12/16
TRC
Product number
B820015
Product name
B2
Packaging
1mg
Price
$200
Updated
2021/12/16
Usbiological
Product number
254701
Product name
B2
Packaging
10mg
Price
$403
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0008461
Product name
CPNQ
Purity
95.00%
Packaging
10MG
Price
$673.08
Updated
2021/12/16
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CPNQ Chemical Properties,Usage,Production

Uses

B2 is a cell permeable inhibitor of SIRT2 (sirtuin 2). Multidrug resistance protein 4 (MRP4) inhibitor in tumors such as neuroblastoma and colorectal cancer.

Definition

ChEBI: (4-chlorophenyl)-[4-(8-nitro-5-quinolinyl)-1-piperazinyl]methanone is a N-arylpiperazine.

Biological Activity

Promotes inclusion formation in cellular models of Huntington's disease and Parkinson's disease. Prevents huntingtin-mediated proteasome dysfunction and reduces α -synuclein-mediated toxicity.

IC 50

SIRT2

CPNQ Preparation Products And Raw materials

Raw materials

Preparation Products

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CPNQ Suppliers

China 44 Switzerland 1 United Kingdom 1 United States 8 Global 54
3B Pharmachem (Wuhan) International Co.,Ltd.
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115687-05-3, CPNQRelated Search:

Oseltamivir phosphate 1-[4-(4-AMINO-PHENYL)-PIPERAZIN-1-YL]-ETHANONE CPNQ 4-(4-BENZYLPIPERAZINO)ANILINE 1-BENZYL-4-(4-NITROPHENYL)PIPERAZINE (4-CHLOROPHENYL)(PIPERAZIN-1-YL) METHANONE 1-Acetyl-4-(4-nitrophenyl)piperazine 1-(4-Nitrophenyl)piperazine

  • 5-[4-(4-Chlorobenzoyl)-1-piperazinyl]-8-nitroquinoline
  • B2
  • Linazolamide intermediate B impurity 2
  • (4-chlorophenyl)-[4-(8-nitroquinolin-5-yl)piperazin-1-yl]methanone
  • SIRT2 Inhibitor, B2
  • Methanone, (4-chlorophenyl)[4-(8-nitro-5-quinolinyl)-1-piperazinyl]-
  • Sirtuin,Parkinson’s diseases,Huntington’s diseases,Inhibitor,B2,inhibit,B-2
  • SIRT2-IN-8
  • CPNQ
  • 115687-05-3