1-(4-Thiazolyl)-ethanone Chemical Properties

Melting point:

56℃

Boiling point:

220℃

Density 

1.226

Flash point:

87℃

storage temp. 

Sealed in dry,Room Temperature

form 

solid

pka

0.19±0.10(Predicted)

color 

Cream

Safety Information

HS Code 

2934100090

1-(4-Thiazolyl)-ethanone Usage And Synthesis

Synthesis

(C) Synthesis of 1-thiazol-4-yl-ethanone (4). A mixed solution of compound 3 (2.4 g, 12.4 mmol) with 4 mL of 5% HCl in 40 mL of THF was stirred at room temperature for 1 hour. After completion of the reaction, the mixture was diluted with ether, washed sequentially with saturated NaHCO3 solution, dried over anhydrous Na2SO4, and concentrated under reduced pressure to afford 1.44 g (94% yield) of the target product 4, which was in the form of an oil and could be used in the subsequent reaction without further purification.

References

[1] Patent: WO2004/87698, 2004, A2. Location in patent: Page 37; 50

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