ETHYL 2-(2-FORMYLAMINO-1,3-THIAZOL-4-YL)-2-OXOACETATE Chemical Properties

Melting point:

232-234 °C

Boiling point:

381.3±34.0 °C(Predicted)

Density 

1.5150 (rough estimate)

refractive index 

1.5690 (estimate)

storage temp. 

2-8°C

solubility 

Chloroform (Slightly, Heated), DMSO (Slightly)

pka

8.11±0.70(Predicted)

form 

Solid

color 

Light Yellow

CAS DataBase Reference

64987-03-7(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

36/37/38-22

Safety Statements 

36/37/39-26-37/39

HS Code 

29341000

MSDS

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ETHYL 2-(2-FORMYLAMINO-1,3-THIAZOL-4-YL)-2-OXOACETATE Usage And Synthesis

Chemical Properties

light yellow powder

Uses

Ethyl 2-(2-Formamidothiazol-4-yl)-2-oxoacetate is an intermediate formed in the synthesis of Cefixime Ethyl Ester Sodium Salt (C242830), an ester impurity of the third generation cephalosporin antibiotic, Cefixime (C242800).

Synthesis

A mixture of ethylene acetate tetrahydrate (120 g), acetic acid (1000 ml) and acetic anhydride (100 ml) was stirred in an oil bath heated to 130??C to 135??C for 20 minutes and potassium permanganate (20 g) was added to the mixture over a period of 5 minutes with stirring at 105??C to 110??C. The mixture was then stirred further at 130??C to 135??C for 30 minutes. The mixture was cooled to room temperature and ethyl 2-(2-formylaminothiazol-4-yl)acetate (53.5 g) was added to the mixture. The mixture was then stirred by introducing air at a rate of 6000 ml at 38??C to 40??C for 15 hrs. per minute. After the reaction, the precipitate was collected by filtration. The precipitate was washed sequentially with acetic acid and water and then dried to give ethyl 2-(2-formylaminothiazol-4-yl)glyoxylate (ethylamino thiazole, 41.5 g) with a melting point of 232-233??C (decomposition).

ETHYL 2-(2-FORMYLAMINO-1,3-THIAZOL-4-YL)-2-OXOACETATE(64987-03-7)Related Product Information

• Sodium ethylxanthogenate
• Ethyl maltol
• Methyl 2-oxoacetate
• 4-Methylthiazole
• Ethyl 2-amino-4-thiazoleacetate
• Pyruvic acid
• (2-Formamido-1,3-thiazol-4-yl)glyoxylic acid
• 2-Aminothiazole-4-acetic acid
• 2-Formamidothiazol-4-acetic acid
• 2-(2-Aminothiazol-4-yl)glyoxylic acid
• Ethyl 2-formamidothiazol-4-acetate
• Ethyl 2-(2-aminothiazol-4-yl)glyoxylate
• 2-Amino-4-methylthiazole
• 2-(1,3-thiazol-4-yl)acetic acid
• 3-CHLORO-2-METHYLBENZYLAMINE
• Ethyl pyruvate
• Thiazole-4-carboxaldehyde
• Ethyl glyoxalate