Basic information Uses Safety Supplier Related
ChemicalBook >  Product Catalog >  Flavors and fragrances >  Synthetic fragrances >  Carboxylic acids and esters >  Carboxylic acids >  Pyruvic acid

Pyruvic acid

Basic information Uses Safety Supplier Related

Pyruvic acid Basic information

Product Name:
Pyruvic acid
Synonyms:
  • 2-oxo-propanoicaci
  • CH3COCOOH
  • Propanoic acid, 2-oxo-
  • PYRUVIC ACID, GR 99%
  • ACID PYRUVATE
  • PyruvicAcidForSynthesis
  • PyruvicAcid,FreeAcid
  • Pyruvic acid, extra pure, 98%
CAS:
127-17-3
MF:
C3H4O3
MW:
88.06
EINECS:
204-824-3
Product Categories:
  • Nutritional Supplements
  • PyruvicAcidSeries
Mol File:
127-17-3.mol
More
Less

Pyruvic acid Chemical Properties

Melting point:
11-12 °C (lit.)
Boiling point:
165 °C (lit.)
Density 
1.267 g/mL at 25 °C (lit.)
FEMA 
2970 | PYRUVIC ACID
refractive index 
n20/D 1.428(lit.)
Flash point:
183 °F
storage temp. 
2-8°C
solubility 
Miscible with chloroform and methanol.
pka
2.39(at 25℃)
form 
Liquid
color 
Clear colorless to light yellow or amber
PH
1.2 (90g/l, H2O, 20℃)
JECFA Number
936
Merck 
14,8021
BRN 
506211
Stability:
Stable. Combustible. Incompatible with strong oxidizing agents, strong bases. Refrigerate.
InChIKey
LCTONWCANYUPML-UHFFFAOYSA-N
CAS DataBase Reference
127-17-3(CAS DataBase Reference)
NIST Chemistry Reference
Pyruvic acid(127-17-3)
EPA Substance Registry System
Propanoic acid, 2-oxo- (127-17-3)
More
Less

Safety Information

Hazard Codes 
C
Risk Statements 
34
Safety Statements 
26-36/37/39-45-25-27
RIDADR 
UN 3265 8/PG 2
WGK Germany 
3
RTECS 
UZ0829800
Autoignition Temperature
305 °C
TSCA 
Yes
HazardClass 
8
PackingGroup 
II
HS Code 
29335995

MSDS

More
Less

Pyruvic acid Usage And Synthesis

Uses

Intermediate in sugar metabolism and in enzymatic carbohydrate degradation (alcoholic fermentation) where it is converted to acetaldehyde and CO2 by carboxylase. In muscle, Pyruvic acid (derived from glycogen) is reduced to lactic acid during exertion, which is reoxidized and partially retransformed to glycogen during rest. The liver can convert Pyruvic acid to alanine by amination. A diagnostic agent for Parkinson disease.

Chemical Properties

Colorless to light yellow liquid

Chemical Properties

Pyruvic acid has a sour, acetic odor (similar to acetic acid). It has a pleasant, sour taste with a burning, somewhat sweet note. It tends to darken and decompose unless kept free of minor contaminants and in tightly sealed containers

Occurrence

Isolated from cane sugar fermentation broth and from a few plants; also reported found in peppermint, raw asparagus, leaves and stalk of celery, onion, rutabaga, milk, cream, buttermilk, wheaten bread, blue cheeses, cheddar cheese, cottage cheese, provolone cheese, yogurt, beef, Virginia tobacco, beer, white wine, botrytised wine, cocoa and sake.

Uses

pyruvic acid is an alpha hydroxy acid that can be irritating and is considered difficult to work with. It has a larger molecular size than the most commonly used AHAs. Sodium pyruvate is more commonly used, and is an organic salt.

Uses

Biochemical research.

Definition

A fundamen- tal intermediate in protein and carbohydrate metabolism in the cell.

Preparation

By distillation of tartaric acid in the presence of potassium acid sulfate as a dehydrating agent; from acetyl chloride and potassium cyanide to yield the nitrile, which is subsequently acid hydrolyzed to the acid; pyruvic acid must be rectified under vacuum.

Aroma threshold values

Aroma characteristics at 1.0%: acidic, sweet, caramellic and sour.

Taste threshold values

Taste characteristics at 5 ppm: sharp acidic, sour fruity, with sour creamy and caramellic nuances.

Biotechnological Applications

Pyruvic acid is a key position in cell metabolism and is involved in many catabolic and anabolic pathways, including glycolysis, gluconeogenesis, amino acid, and protein metabolism. Pyruvic acid is employed for the production of L-tryptophan, L-tyrosine, and 3,4-dihydroxyphenyl alanine in various industries. The diet supplementation with pyruvic acid increased fat loss and minimized the associated loss of body protein. Pyruvic acid is also used in biochemical researches and medicine as a substrate for assaying activities of such enzymes as pyruvate dehydrogenase, pyruvate carboxylase, and pyruvate decarboxylase (Nakazawa et al. 1972; Yamada et al. 1972; Stanko et al. 1992).
Y. lipolytica oxidize glucose and form pyruvic acid (75–80 %) and a-ketoglutaric acid (20–25 %) under thiamine deficiency conditions. The synthesis of the acid was triggered by a decrease in intracellular thiamine concentration to 3.0 lg per 1 g biomass. An approximately 3-fold increase in the amount of the biomass was associated with a subsequent decrease in thiamine content to the level of 1.0 lg per 1 g biomass, whose maximum production of pyruvic acid was 50 g/L in this condition. In addition to glucose, thiamine-auxotrophic yeasts are capable of synthesizing pyruvic acid when grown on glycerol and propionic acid. Technicalgrade glycerol is the most promising raw material for pyruvic acid production. Pyruvic acid was obtained at a concentration of 61 g/L with a yield of 71 % from glycerol (Morgunov et al. 2004; Finogenova et al. 2005).

Purification Methods

Distil it twice, then fractionally crystallise it by partial freezing. [Beilstein 3 IV 1505.]

Pyruvic acidSupplier

Shandong Ono Chemical Co., Ltd. Gold
Tel
0539-6362799(To 20)
Email
68188893@qq.com
Shanghai Worldyang Chemical Co.,Ltd. Gold
Tel
+86-21-56791066;56795766;56795797
Email
sales@worldyachem.com
Shanghai lian lu industrial co., LTD Gold
Tel
021-57937586-
Email
lianluxs013@shllgf.com
卡托研究化学公司 Gold
Tel
020-81215950- ;020-81215950-
Email
customer@uwalab.com;customer@uwalab.com
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Email
jkinfo@jkchemical.com;market6@jkchemical.com