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Ethyl (R)-2-hydroxy-4-phenylbutyrate

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Ethyl (R)-2-hydroxy-4-phenylbutyrate Basic information

Product Name:
Ethyl (R)-2-hydroxy-4-phenylbutyrate
Synonyms:
  • ETHYL-[(R)-(-)-2-HYDROXY-4-PHENYLBUTYRAT]
  • ETHYL (R)-(-)-2-HYDROXY-4-PHENYLBUTYRATE
  • ETHYL (R)-2-HYDROXY-4-PHENYLBUTYRATE
  • Ethyl(R)-2-Hydroxyl-4-PhenylButyrate
  • ethyl (2R)-2-hydroxy-4-phenylbutanoate
  • ETHYL(R)-2-HYDROXY-4-PHENYLBUTANOATE
  • R-(-)-2-Hydroxy-4-Phenyl-Butyric Acid Ethyl Ester (R-Hpbe)
  • (R)-2-Hydroxy-4-phenylbutanoicacidethylester
CAS:
90315-82-5
MF:
C12H16O3
MW:
208.26
EINECS:
618-525-4
Product Categories:
  • Chiral Building Blocks
  • Esters (Chiral)
  • Synthetic Organic Chemistry
  • Chiral Building Blocks
  • Esters
  • Organic Building Blocks
  • Alcohols, Hydroxy Esters and Derivatives
  • chiral
  • (intermediate of benazepril hydrochloride)
  • (intermediate of lisinopril )
  • API
  • Aromatics
  • Chiral Reagents
  • Intermediates
  • Chiral Compounds
Mol File:
90315-82-5.mol
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Ethyl (R)-2-hydroxy-4-phenylbutyrate Chemical Properties

Melting point:
NA
Boiling point:
212 °C(lit.)
alpha 
-10 º (c=neat)
Density 
1.075 g/mL at 20 °C(lit.)
refractive index 
n20/D 1.504(lit.)
Flash point:
>230 °F
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
Chloroform (Slightly), Methanol (Slightly)
pka
13.00±0.20(Predicted)
form 
Liquid
color 
Colorless
optical activity
[α]21/D 10°, neat
Water Solubility 
insoluble
BRN 
3590943
InChIKey
ZJYKSSGYDPNKQS-LLVKDONJSA-N
CAS DataBase Reference
90315-82-5(CAS DataBase Reference)
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Safety Information

Safety Statements 
23-24/25
WGK Germany 
3
HS Code 
29181990

MSDS

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Ethyl (R)-2-hydroxy-4-phenylbutyrate Usage And Synthesis

Chemical Properties

Colorless to light yellow liqui

Uses

Ethyl (R)-(?)-2-hydroxy-4-phenylbutyrate can be used as a key intermediate for the synthesis of various ACE inhibitors like Cilazapril, Benazepril, and Enalapril.

Uses

Ethyl(R)-2-hydroxy-4-phenylbutyrate is used in the preparation of benzothiophenes, benzofurans, and indoles useful in the treatment of insulin resistance and hyperglycemia.

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