Perindoprilat Chemical Properties

Melting point:

153-155°C

Boiling point:

568.1±45.0 °C(Predicted)

Density 

1.222±0.06 g/cm3(Predicted)

storage temp. 

-20°C Freezer

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Solid

pka

2.27±0.20(Predicted)

color 

White to Pale Beige

Stability:

Hygroscopic

CAS DataBase Reference

95153-31-4

Safety Information

HS Code 

2933999552

Perindoprilat Usage And Synthesis

Chemical Properties

White to Off-White Solid

Uses

An angiotensin-converting enzyme (ACE) inhibitor. Antihypertensive.

Uses

Perindoprilat is the active metabolite of perindopril, an inhibitor of angiotensin converting enzyme (ACE) that has efficacy against hypertension. Perindoprilat specifically and competitively inhibits ACE in vitro with IC50 values ranging between 1.5 and 3.2 nM. Elimination of perindoprilat is decreased in the elderly and in patients with heart or renal failure.[Cayman Chemical]

Uses

Perindoprilat is an angiotensin-converting enzyme (ACE) inhibitor and antihypertensive.

Definition

ChEBI: Perindoprilat is a dipeptide obtained by formal condensation of one of the carboxy groups of N-[(1S)-1-carboxyethyl]-L-norvaline with the amino group of (2S,3aS,7aS)-octahydroindole-2-carboxylic acid. The major active metabolite of perindopril. It has a role as an antihypertensive agent, an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor and a drug metabolite. It is an organic heterobicyclic compound, a dipeptide, a dicarboxylic acid and a L-alanine derivative.

Perindoprilat(95153-31-4)Related Product Information

• Betaine
• Glycine
• Sodium carboxyl methylstarch
• ALTRENOGEST
• Perindopril
• PERINDOPRIL ACYL-B-D-GLUCURONIDE
• Perindopril-N-desethylpentanoate
• 1H-Indole-2-carboxylicacid,2,3,4,5,6,7-hexahydro-,(2S)-(9CI)
• (R)-N-(1-Carboxyethyl)-D-norvaline 1-Ethyl Ester
• Perindopril EP Impurity L
• L-Norvaline ethyl ester hydrochloride
• 1H-Indole-2-carboxylicacid,octahydro-,(2R,3aS,7aR)-(9CI)
• (S)-(-)-Indoline-2-carboxylic acid
• (S)-Ethyl 2-((3S,5aS,9aS,10aS)-3-methyl-1,4-dioxodecahydropyrazino[1,2-a]indol-2(1H)-yl)pentanoate ,95%
• Perindoprilat LactaM A
• L-Octahydroindole-2-carboxylic acid
• (+/-)-1''-epi-Perindopril
• Perindopril Impurity 16