8-Bromotheophylline Chemical Properties

Melting point:

295-297°C

Boiling point:

469.5±55.0 °C(Predicted)

Density 

1.862±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

DMSO (Slightly), Methanol (Slightly, Heated)

pka

pKa 5.45±0.1(H2O t=24) (Uncertain)

form 

Solid

color 

White to Off-White

BRN 

203069

CAS DataBase Reference

10381-75-6

EPA Substance Registry System

1H-Purine-2,6-dione, 8-bromo-3,7-dihydro-1,3-dimethyl- (10381-75-6)

Safety Information

Risk Statements 

20/21/22

Safety Statements 

24/25-36/37

RIDADR 

2811

HazardClass 

6.1(b)

PackingGroup 

III

HS Code 

29395900

8-Bromotheophylline Usage And Synthesis

Description

Bromotheophylline is the active moiety of pamabrom, a mixture of 2-amino-2-methyl-propanol and bromotheophylline. From this mixture, bromotheophylline acts as a weak diuretic that has been used along with some analgesics to relieve the symptoms of premenstrual syndrome. Bromotheophylline is categorized on the FDA as a drug substance with an inactive state since March, 1980. It is also approved by Health Canada to be used alone or in combination with [DB00316] in OTC products.

Chemical Properties

White Crystalline Powder

Uses

The active component in the diuretic Diurex.

Purification Methods

It is purified by dissolving in the minimum volume of dilute NaOH (charcoal), filtering and acidifying to pH ca 3.5-4. The solid that separates is collected, dried in vacuo at 100o and stored in a dark container. It has also been recrystallised from EtOH or AcOH. [Blitz & Beck J Prakt Chem [2] 118 158 1928, Fischer & Ach Chem Ber 28 3142 1895, Beilstein 26 H 476, 26 II 227, 26 III/IV 2447.]

8-Bromotheophylline(10381-75-6)Related Product Information

• 8-Bromotheophylline
• 8-BROMOXANTHINE
• 8-BROMO-7-ETHYL-1,3-DIMETHYL-2,3,6,7-TETRAHYDRO-1H-PURINE-2,6-DIONE
• 8-BROMO-7-(3-CHLOROPROPYL)-1,3-DIMETHYL-2,3,6,7-TETRAHYDRO-1H-PURINE-2,6-DIONE
• 8-BROMO-7-(2-BROMOPROPYL)-1,3-DIMETHYL-2,3,6,7-TETRAHYDRO-1H-PURINE-2,6-DIONE
• ETHYL 2-(8-BROMO-1,3-DIMETHYL-2,6-DIOXO-2,3,6,7-TETRAHYDRO-1H-PURIN-7-YL)ACETATE
• 8-BROMO-1,3-DIMETHYL-7-(2-OXO-2-PHENYLETHYL)-2,3,6,7-TETRAHYDRO-1H-PURINE-2,6-DIONE
• 8-BROMO-7-(3-CHLORO-2-HYDROXYPROPYL)-1,3-DIMETHYL-2,3,6,7-TETRAHYDRO-1H-PURINE-2,6-DIONE
• 8-BROMO-7-(2-HYDROXYPROPYL)-1,3-DIMETHYL-2,3,6,7-TETRAHYDRO-1H-PURINE-2,6-DIONE
• AKOS BC-1749
• ETHYL 4-(8-BROMO-1,3-DIMETHYL-2,6-DIOXO-2,3,6,7-TETRAHYDRO-1H-PURIN-7-YL)BUTANOATE
• 8-BROMO-1,3,7-TRIMETHYL-3,7-DIHYDRO-PURINE-2,6-DIONE
• 8-BROMO-1,3-DIMETHYL-7-(2-OXOPROPYL)-2,3,6,7-TETRAHYDRO-1H-PURINE-2,6-DIONE
• 8-BROMO-7-(2-BROMOBUTYL)-1,3-DIMETHYL-2,3,6,7-TETRAHYDRO-1H-PURINE-2,6-DIONE
• 8-BROMO-1,3-DIMETHYL-7-PHENETHYL-2,3,6,7-TETRAHYDRO-1H-PURINE-2,6-DIONE
• 8-BROMO-7-(2-CHLOROBUTYL)-1,3-DIMETHYL-2,3,6,7-TETRAHYDRO-1H-PURINE-2,6-DIONE
• 8-BROMO-7-(2-CHLOROPROPYL)-1,3-DIMETHYL-2,3,6,7-TETRAHYDRO-1H-PURINE-2,6-DIONE
• 8-BROMO-7-(2-HYDROXYBUTYL)-1,3-DIMETHYL-2,3,6,7-TETRAHYDRO-1H-PURINE-2,6-DIONE