18,19-Dinorpregn-4-en-20-yn-3-one-2,2,4,6,6,10-d6, 13-ethyl-17-hydroxy-, (17α)- Chemical Properties

solubility 

DMF: 5 mg/ml; DMSO: 5 mg/ml; Ethanol: 0.5 mg/ml

form 

A solid

color 

White to off-white

18,19-Dinorpregn-4-en-20-yn-3-one-2,2,4,6,6,10-d6, 13-ethyl-17-hydroxy-, (17α)- Usage And Synthesis

Description

Levonorgestrel-d₆ is intended for use as an internal standard for the quantification of levonorgestrel by GC- or LC-MS. Levonorgestrel is a synthetic progestin and the biologically active component of norgestrel .¹ In vivo, levonorgestrel (60 μg/day) suppresses estrus and pregnancy in female cats.² Post-coital insertion of subdermal levonorgestrel (5 mg pellet) implants prevents uterine implantation of embryos in mice.³ Formulations containing levonorgestrel have been used as contraceptives.

Uses

Norgestrel-d6 is the deuterium labeled Levonorgestrel. Levonorgestrel is a synthetic progestogen used as an active ingredient in some hormonal contraceptives. Norgestrel-d6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

References

1. Jones, R.C., Singer, A.C., and Edgren, R.A. The biological activities of norgestrel and its enantiomers Int. J. Fertil. 24(1),39-43(1979).
2. Baldwin, C.J., Peter, A.T., Bosu, W.T., et al. The contraceptive effects of levonorgestrel in the domestic cat Lab. Anim. Sci. 44(3),261-269(1994).
3. Shirley, B., Bundren, J.C., and McKinney, S. Levonorgestrel as a postcoital contraceptive Contraception 52(2),277-281(1995).

18,19-Dinorpregn-4-en-20-yn-3-one-2,2,4,6,6,10-d6, 13-ethyl-17-hydroxy-, (17α)-(2376035-98-0)Related Product Information

• 13-Ethyl-10,17-dihydroxy-18,19-dinor-17α-pregn-4-en-20-yn-3-one
• Levonorgestrel-3,17-diacetate
• Levonorgestrel Impurity 16
• 6-Oxo D-(-)-Norgestrel
• (±)-13-ethyl-3-methoxygona-2,5(10)-dien-17beta-ol
• 13-Ethyl-3-methoxygona-1,3,5(10),8-tetraen-17beta-ol
• 13-ethyl-3-methoxy-18,19-dinor-17alpha-pregna-2,5(10)-dien-20-yn-17-ol
• 18,19-Dinorpregna-4,6,8(14)-trien-20-yn-3-one, 13-ethyl-17-hydroxy-, (17α)-
• 6β-Hydroxy Norgestrel
• Levonorgestrel EP Impurity I
• 13-Ethyl-17-hydroxy-18,19-dinorpregn-5(10)-en-20-yn-3-one
• 5α-Dihydrolevonorgestrel
• (-)-NORGESTREL 98
• 6-Hydroxy-levonorgestrel
• 18-Methyl Nandrolone
• Δ5(10),6,8(9)-D-(-)-Norgestrel
• (±)-13-ethyl-3-methoxy-18,19-dinor-17alpha-pregna-2,5(10)-dien-20-yn-17-ol
• [2R-[2alpha(E),3beta]]-2-[2-(3,4-dihydro-6-methoxy-1(2H)-naphthylidene)ethyl]-2-ethyl-3-hydroxycyclopentan-1-one