4-BROMO-2-CHLOROANISOLE Chemical Properties

Melting point:

68.5-70.5°C

Boiling point:

242℃

Density 

1.564

Flash point:

100℃

storage temp. 

Sealed in dry,Room Temperature

Appearance

Off-white to pale purple Solid

Safety Information

HS Code 

2909309090

4-BROMO-2-CHLOROANISOLE Usage And Synthesis

Uses

4-Bromo-2-chloro-1-methoxybenzene is used in the preparation of allosteric inhibitors hepatitis C polymerase in the form of dihydropyrones. Also used in the discovery of 5-HT6 reveptor ligands affecting serotonin levels and potential application to neuropsychopharmacology.

References

[1] Patent: US2009/209529, 2009, A1. Location in patent: Page/Page column 24
[2] Patent: US4623650, 1986, A
[3] Angewandte Chemie - International Edition, 2014, vol. 53, # 25, p. 6443 - 6448
[4] Angew. Chem., 2014, vol. 126, # 25, p. 6561 - 6566
[5] Angewandte Chemie - International Edition, 2013, vol. 52, # 35, p. 9144 - 9148

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