Robinin
Robinin Basic information
- Product Name:
- Robinin
- Synonyms:
-
- KAEMPFEROL-3-O-ROBINOSIDE-7-O-RHAMNOSIDE
- KAEMPFEROL 3-O-ROBINOSIDE 7-RHAMNOSIDE
- KAEMPFEROL 3-ROBINOSIDE 7-RHAMNOSIDE
- ROBININ
- 4h-1-benzopyran-4-one,3-((6-o-(6-deoxy-alpha-l-mannopyranosyl)-beta-d-galactop
- kaempferol-3-o-gal-rham-7-o-rham
- yranosyl)oxy)-7-((6-deoxy-alpha-l-mannopyranosyl)oxy)-5-hydroxy-2-(4-hydroxyph
- 3-[[6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-galactopyranosyl]oxy]-7-[(6-deoxy-alpha-L-mannopyranosyl)oxy]-5-hydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
- CAS:
- 301-19-9
- MF:
- C33H40O19
- MW:
- 740.66
- EINECS:
- 206-113-3
- Product Categories:
-
- Flavanols
- Mol File:
- 301-19-9.mol
Robinin Chemical Properties
- Melting point:
- 194-195°C
- Boiling point:
- 1064.4±65.0 °C(Predicted)
- Density
- 1.74±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in hot water
- form
- powder
- pka
- 5.81±0.40(Predicted)
- color
- light yellow crystal. hydrate: light yellow needles.
- Water Solubility
- soluble in hot water.
- LogP
- 0.890 (est)
- CAS DataBase Reference
- 301-19-9
Safety Information
- Safety Statements
- 22-24/25
- WGK Germany
- 3
Robinin Usage And Synthesis
Chemical Properties
Robinin is a flavone belonging to the flavonol glycosides occurring in Robinia species, e. g., Robinia pseudoacacia (Fabaceae) and in Pueraria and Vigna species (Fabaceae). Robinin has been reported to have antibacterial activity.
Uses
food and beverages
Definition
ChEBI: Robinin is a glycosyloxyflavone that is kaempherol substituted by a 6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-galactopyranosyl residue at position 3 and a 6-deoxy-alpha-L-mannopyranosyl residue at position 7 via a glycosidic linkage. It has a role as a plant metabolite. It is a glycosyloxyflavone and a dihydroxyflavone. It is functionally related to a kaempferol.
in vivo
The combination of Robinin and methotrexate (50 mg/kg and 0.3 mg/kg, Oral gavage, Twice a week) has anti-inflammatory and anti-arthritic action in adjuvant arthritis mice models[3].
Robinin (50 mg/kg, Oral gavage, 10 days) can modulate the cardioprotective effect of the TGF-β1 signaling pathway on Adriamycin-induced cardiotoxicity[4].
| Animal Model: | Adjuvant arthritis mice model[3] |
| Dosage: | 50 mg/kg Robinin and 0.3 mg/kg MTX twice a week |
| Administration: | Oral gavage (p.o.) |
| Result: | Had anti-inflammatory and anti-arthritic action. |
| Animal Model: | Sprague Dawley rats model[4] |
| Dosage: | 50 mg/kg Robinin for 10 days |
| Administration: | Oral gavage (p.o.) |
| Result: | Reduced the cardiotoxic effects of Doxorubicin-induced |
IC 50
TLR2; TLR4
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Robinin(301-19-9)Related Product Information
- Robinin
- 4'-ETHOXYACETOPHENONE
- 1-(2-(((1-ETHYLOXY)ETHYL)OXY)ETHYL)BENZENE
- 4-METHOXYPHENETHYL ALCOHOL
- Diethylene glycol monobutyl ether
- 2',4',6'-Trihydroxyacetophenone monohydrate
- Salidroside
- 3,7-DIHYDROXYFLAVONE
- Triethylene glycol
- 4-N-BUTOXYBENZALDEHYDE
- 4-N-HEXYLOXYBENZALDEHYDE
- METHYL ALPHA-L-RHAMNOPYRANOSIDE
- L-LYXOSE
- α-L-Rhamnopyranose monohydrate
- TRIPROPYLENE GLYCOL
- [2-(1-Propoxyethoxy)ethyl]benzene
- KAEMPFEROL-3-O-RUTINOSIDE
- Kaempferol