5'-Amino-2'-hydroxyacetophenone Chemical Properties

Melting point:

121–122°C

Boiling point:

335.4±27.0 °C(Predicted)

Density 

1.242±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

pka

10.42±0.18(Predicted)

Appearance

Light yellow to yellow Solid

Safety Information

HS Code 

2914500090

5'-Amino-2'-hydroxyacetophenone Usage And Synthesis

Uses

1-(5-Amino-2-hydroxyphenyl)ethanone is used in the preparation of alkylated flavonoid compounds for use as therapeutic antioxidants. It is also used to synthesize spiro[chromanone-piperidine]s as acetyl-CoA carboxylase inhibitors.

Preparation

Also obtained by refluxing a suspension of N-(3-acetyl-4- hydroxyphenyl)acetamide in 15% hydrochloric acid for 40 min (84%).

Synthesis

The hydrolysis reaction was carried out by refluxing 2-hydroxy-5-acetamidoacetophenone in 2N hydrochloric acid solution for 6 hours to obtain 5-amino-2-hydroxyacetophenone in 94% yield.

References

[1] Journal of Medicinal Chemistry, 1992, vol. 35, # 21, p. 3973 - 3976
[2] Patent: US2007/117823, 2007, A1. Location in patent: Page/Page column 8
[3] Patent: WO2007/54580, 2007, A1. Location in patent: Page/Page column 16
[4] European Journal of Medicinal Chemistry, 1991, vol. 26, # 9, p. 843 - 851
[5] Bioorganic and Medicinal Chemistry, 2004, vol. 12, # 9, p. 2079 - 2098

5'-Amino-2'-hydroxyacetophenone(50-80-6)Related Product Information

• CI 63010
• Acid Violet 43
• ALIZARIN SAFIROL SE
• 1,5-DIAMINO-4,8-DIHYDROXYANTHRAQUINONE
• Acebutolol hydrochloride
• 1-Amino-2-bromo-4-hydroxy-9,10-anthraquinone
• 1 8-DIAMINO-4 5-DIHYDROXYANTHRAQUINONE
• 1,5-DIHYDROXY-4,8-DINITROANTHRAQUINONE
• Celliton Fast Pink B
• DISPERSE RED 60
• 1-AMINO-2-CHLORO-4-HYDROXY-9,10-ANTHRACENEDIONE
• Solvent Violet 13
• Minocycline
• 1,8-Dihydroxy-4,5-dinitroanthraquinone
• NUCLEAR FAST RED
• EOSIN TOLUIDINE BLUE
• 7-AMINO-1-AZAXANTH-5-ONE
• ALIZARIN BLUE BLACK BG