3-Keto-N-aminoethyl-Naminocaproyldihydrocinnamoyl Cyclopamine
3-Keto-N-aminoethyl-Naminocaproyldihydrocinnamoyl Cyclopamine Basic information
- Product Name:
- 3-Keto-N-aminoethyl-Naminocaproyldihydrocinnamoyl Cyclopamine
- Synonyms:
-
- 3-Keto-N-aMinoethyl-N'-aMinocaproyldihydrocinnaMoyl CyclopaMine, >80%
- Benzenepropanamide, N-[6-[[2-[(3'R,3'aS,6'S,6aS,6bS,7'aR,2'R,11aS,11bR)-1,2,3,3',3'a,4,5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-octadecahydro-3',6',10,11b-tetramethyl-3-oxospiro[9H-benzo[a]fluorene-9,2'(4'H)-furo[3,2-b]pyridin]-4'-yl]ethyl]amino]-6-oxohexyl]-
- KAAD Cyclopamine,KAADCyclopamine
- CAS:
- 306387-90-6
- MF:
- C44H63N3O4
- MW:
- 697.999
- Product Categories:
-
- Inhibitors
- Steroids
- Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals, Steroids
- Mol File:
- 306387-90-6.mol
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3-Keto-N-aminoethyl-Naminocaproyldihydrocinnamoyl Cyclopamine Chemical Properties
- Boiling point:
- 875.6±65.0 °C(Predicted)
- Density
- 1.15±0.1 g/cm3(Predicted)
- storage temp.
- Hygroscopic, -20°C Freezer, Under Inert Atmosphere
- solubility
- Chloroform: Slightly soluble; Methanol: Slightly soluble
- form
- A solid
- pka
- 16.10±0.46(Predicted)
- CAS DataBase Reference
- 306387-90-6
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3-Keto-N-aminoethyl-Naminocaproyldihydrocinnamoyl Cyclopamine Usage And Synthesis
Chemical Properties
Pale Yellow Solid
Uses
Cyclopamine demonstrates teratogenic properties and has been shown to reverse effects ofoncogenic mutations in Smoothened and Patched.1 The KAAD derivative has shown 10-20 fold higher potency than cyclopamine in inhibition of ?-Galactosidase expression i
Uses
Cyclopamine demonstrates teratogenic properties and has been shown to reverse effects of oncogenic mutations in Smoothened and Patched.1 The KAAD-Cyclopamine has shown 10-20 fold higher potency than cyclopamine in inhibition of ?-Galactosidase expression in p2Ptch-1- cells, with similar or lower toxicity.KAAD-Cyclopamine compound is unstable in solution.
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