Basic information Safety Supplier Related

3-Keto-N-aminoethyl-Naminocaproyldihydrocinnamoyl Cyclopamine

Basic information Safety Supplier Related

3-Keto-N-aminoethyl-Naminocaproyldihydrocinnamoyl Cyclopamine Basic information

Product Name:
3-Keto-N-aminoethyl-Naminocaproyldihydrocinnamoyl Cyclopamine
Synonyms:
  • 3-Keto-N-aMinoethyl-N'-aMinocaproyldihydrocinnaMoyl CyclopaMine, >80%
  • Benzenepropanamide, N-[6-[[2-[(3'R,3'aS,6'S,6aS,6bS,7'aR,2'R,11aS,11bR)-1,2,3,3',3'a,4,5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-octadecahydro-3',6',10,11b-tetramethyl-3-oxospiro[9H-benzo[a]fluorene-9,2'(4'H)-furo[3,2-b]pyridin]-4'-yl]ethyl]amino]-6-oxohexyl]-
  • KAAD Cyclopamine,KAADCyclopamine
  • 3-Keto-N-aminoethyl-N’-aminocaproyldihydrocinnamoyl Cyclopamine
CAS:
306387-90-6
MF:
C44H63N3O4
MW:
697.999
Product Categories:
  • Inhibitors
  • Steroids
  • Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals, Steroids
Mol File:
306387-90-6.mol
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3-Keto-N-aminoethyl-Naminocaproyldihydrocinnamoyl Cyclopamine Chemical Properties

Boiling point:
875.6±65.0 °C(Predicted)
Density 
1.15±0.1 g/cm3(Predicted)
storage temp. 
Hygroscopic, -20°C Freezer, Under Inert Atmosphere
solubility 
Chloroform: Slightly soluble; Methanol: Slightly soluble
form 
A solid
pka
16.10±0.46(Predicted)
color 
White to light yellow
CAS DataBase Reference
306387-90-6
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3-Keto-N-aminoethyl-Naminocaproyldihydrocinnamoyl Cyclopamine Usage And Synthesis

Chemical Properties

Pale Yellow Solid

Uses

Cyclopamine demonstrates teratogenic properties and has been shown to reverse effects ofoncogenic mutations in Smoothened and Patched.1 The KAAD derivative has shown 10-20 fold higher potency than cyclopamine in inhibition of ?-Galactosidase expression i

Uses

Cyclopamine demonstrates teratogenic properties and has been shown to reverse effects of oncogenic mutations in Smoothened and Patched.1 The KAAD-Cyclopamine has shown 10-20 fold higher potency than cyclopamine in inhibition of ?-Galactosidase expression in p2Ptch-1- cells, with similar or lower toxicity.KAAD-Cyclopamine compound is unstable in solution.

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3-Keto-N-aminoethyl-Naminocaproyldihydrocinnamoyl Cyclopamine(306387-90-6)Related Product Information