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Deoxyharringtonine

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Deoxyharringtonine Basic information

Product Name:
Deoxyharringtonine
Synonyms:
  • Deoxyharringtonine
  • (2R)-2-Hydroxy-2-(methoxycarbonyl)methyl-5-methylhexanoic acid (1S,3aR)-1,5,6,8,9,14bβ-hexahydro-2-methoxy-4H-cyclopenta[a][1,3]dioxolo[4,5-h]pyrrolo[2,1-b][3]benzazepin-1-yl ester
  • Cephalotaxine, 3-[4-methyl (2R)-2-hydroxy-2-(3-methylbutyl)butanedioate]
CAS:
36804-95-2
MF:
C28H37NO8
MW:
515.6
Mol File:
36804-95-2.mol
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Deoxyharringtonine Chemical Properties

Boiling point:
645.8±55.0 °C(Predicted)
Density 
1.30±0.1 g/cm3(Predicted)
pka
11.60±0.29(Predicted)
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Deoxyharringtonine Usage And Synthesis

Uses

Deoxyharringtonine is an alkaloid isolated from Cephalotaxus genus with significant anti-leukemic activity[1].

References

[1] Joseph D Eckelbarger, et al. Synthesis of antiproliferative Cephalotaxus esters and their evaluation against several human hematopoietic and solid tumor cell lines: uncovering differential susceptibilities to multidrug resistance. Chemistry. 2008;14(14):4293-306. DOI:10.1002/chem.200701998

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