4-PYRIDYLTHIOUREA Chemical Properties

Melting point:

174 °C

Boiling point:

298.7±32.0 °C(Predicted)

Density 

1.382±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

form 

Solid

pka

11.79±0.70(Predicted)

BRN 

386892

CAS DataBase Reference

164670-44-4(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

25-22

Safety Statements 

22-36/37

RIDADR 

2811

Hazard Note 

Irritant

HazardClass 

6.1

PackingGroup 

III

HS Code 

2933399990

MSDS

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4-PYRIDYLTHIOUREA Usage And Synthesis

Uses

It is an intermediate of thiazoles.

Definition

ChEBI: N-(4-pyridyl)thiourea is a dihydropyridine.

Synthesis

P-pyridylthiourea was prepared as follows: 1,1-thiocarbonyldiimidazole (29.4 g, 0.16 mol) was added to an anhydrous tetrahydrofuran (600 mL) solution of 4-aminopyridine (14.1 g, 0.15 mol) and the resultant mixture was stirred for 17 hours. The solvent was removed under reduced pressure and the resulting solid was suspended in a mixture of dichloromethane and water. The undissolved solid was filtered and then washed with acetone to give a solid product (8.98 g). Gaseous ammonia was bubbled through a solution of anhydrous tetrahydrofuran (250 mL) of the resulting solid product (8.50 g, 0.06 mol) for 20 minutes. The ammonia flow was stopped and the mixture was stirred for 17 h, during which time a precipitate formed in the reaction. Filtering and then drying the solid under vacuum gave the desired thiourea product p-pyridylthiourea (5.1 g).

4-PYRIDYLTHIOUREA(164670-44-4)Related Product Information

• 2-Hydrazinopyridine
• 2-Cyanopyridine
• 3-PYRIDIN-4-YLANILINE
• 2-Acetylpyridine
• Thiourea
• tris(trimethylsilyl)silicon
• 4-PYRIDYLTHIOUREA
• BUTTPARK 38\09-70
• N-Methyl-4-pyridinamine