DIPHENYL PHOSPHITE Chemical Properties

Melting point:

12 °C (lit.)

Boiling point:

218-219 °C/26 mmHg (lit.)

Density 

1.223 g/mL at 25 °C (lit.)

vapor density 

8.1 (vs air)

vapor pressure 

5 mm Hg ( 140 °C)

refractive index 

n20/D 1.558(lit.)

Flash point:

350 °F

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

form 

Liquid

Specific Gravity

1.223

color 

Clear

BRN 

2051909

InChIKey

OGBPILLJZSJJRC-UHFFFAOYSA-N

LogP

2.4 at 25℃ and pH7

CAS DataBase Reference

4712-55-4(CAS DataBase Reference)

EPA Substance Registry System

Diphenyl phosphite (4712-55-4)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-37/38-41

Safety Statements 

26-39

RIDADR 

1760

WGK Germany 

3

F 

21

HazardClass 

8

PackingGroup 

III

HS Code 

29209090

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

DIPHENYL PHOSPHITE Usage And Synthesis

Chemical Properties

clear liquid

Uses

Diphenyl Phosphite is a reactant used in the synthesis of α-hydroxyphosphonates and α-hydroxyphosphinates for their antioxidant and antimicrobial activity.

Synthesis

In a three-necked round-bottomed flask equipped with a mechanical stirrer, a reflux condenser and a dropping funnel, the first P-O component (PIII-OH) is added under nitrogen protection. This P-O component (see column 5 of Table 1) may be selected from H3PO3, monoalkyl phosphite or mixtures thereof and may additionally comprise dialkyl phosphite. Subsequently, the first P-O component is heated to the temperature specified in column 11 of Table 1 (T° step a) for step a). Next, the second P-O component (see column 6 of Table 1) is added while maintaining the appropriate temperature. The mixture was allowed to react for the time indicated in column 13 of Table 1 (reaction time step a), followed by step b). The alcohol R1-OH (see column 3 of Table 1) is then added dropwise while maintaining the temperature specified in column 12 of Table 1 (T° step b). After the mixture was reacted for the time indicated in column 14 of Table 1 (reaction time b), it was cooled to room temperature and analyzed by 31P NMR.

Purification Methods

Diphenyl Phosphite can be purified by distillation. Best done in small batches since decomposition frequently occurs. Phenol can be substantially removed by heating at 150 °C at water pump vacuum.

References

[1] Patent: EP2581378, 2013, A1. Location in patent: Paragraph 0038; 0039; 0043

DIPHENYL PHOSPHITE(4712-55-4)Related Product Information

• Triphenyl phosphate
• Glycol sulfite
• Dimethyl phosphite
• Triethyl phosphite
• DI-N-PROPYL SULFITE
• DIAMYL SULFITE
• TETRAETHYL ETHYLENEDIPHOSPHONATE
• DIETHYL ETHYLIDENEMALONATE
• GLYOXAL SODIUM BISULFITE
• SODIUM PHOSPHITE-5-HYDRATE
• Monopotassium phosphite
• LINOLENIC ACID ETHYL ESTER
• PHOSPHOROUS ACID TRI-O-CRESYL ESTER
• Dibenzyl phosphite
• METHYL LINOLENATE
• Diisopropyl phosphite
• Phosphorous acid, bis(1-methylethyl) ester
• Dimethyl sulfite