(1S,4R)-4-Amino-2-cyclopenten-1-carboxylic Acid Hydrochloride Chemical Properties

Melting point:

>260 °C (decomp)(Solv: water (7732-18-5); acetone (67-64-1))

Boiling point:

266.6±40.0 °C(Predicted)

Density 

1.248±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

pka

3.52±0.20(Predicted)

InChI

InChI=1S/C6H9NO2/c7-5-2-1-4(3-5)6(8)9/h1-2,4-5H,3,7H2,(H,8,9)/t4-,5+/m1/s1

InChIKey

VTCHZFWYUPZZKL-UHNVWZDZSA-N

SMILES

[C@H]1(C(O)=O)C[C@@H](N)C=C1

(1S,4R)-4-Amino-2-cyclopenten-1-carboxylic Acid Hydrochloride Usage And Synthesis

Uses

(1S,4R)-4-Amino-2-cyclopenten-1-carboxylic Acid is a γ-aminobutyric acid mimetic drug that affect dopaminergic activity.

Synthesis

Dissolve 10g of (1S, 4R)-4-aminocyclopent-2-ene-1-carboxylic acid methyl ester tartrate in 50mL of methanol, add triethylamine to neutralize to Ph6-7, add 10mL of water and cool to -20 , 5mL of lithium hydroxide aqueous solution (containing 0.16g of lithium hydroxide) was added dropwise, immediately after the reaction was neutralized with acetic acid to pH 3-4, the organic solvent was vortexed and diluted with tetrahydrofuran, the salt was filtered off and vortexed to obtain (1S,4R)-4-Amino-2-cyclopenten-1-carboxylic Acid Hydrochloride 3.6 g, yield 83.7%.