PC cell-derived growth factor Chemical Properties

storage temp. 

-20°C

form 

lyophilized

color 

white

biological source

rat

Safety Information

WGK Germany 

WGK 2

Storage Class

12 - Non Combustible Liquids

PC cell-derived growth factor Usage And Synthesis

Uses

Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer′s Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.

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