Raloxifene-d10 Chemical Properties

Boiling point:

728.193±60.00 °C(Press: 760.00 Torr)(predicted)

Density 

1.289±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)

Raloxifene-d10 Usage And Synthesis

Uses

Raloxifene-d10-1 is the deuterium labeled Raloxifene[1]. Raloxifene (Keoxifene) is a benzothiophene-derived selective estrogen receptor modulator (SERM). Raloxifene has estrogen-agonistic effects on bone and lipids and estrogen-antagonistic effects on the breast and uterus. Raloxifene is used for breast cancer and osteoporosis research[2].

References

[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. DOI:10.1177/1060028018797110
[2] Khovidhunkit W, et al. Clinical effects of raloxifene hydrochloride in women. Ann Intern Med. 1999;130(5):431-439. DOI:10.7326/0003-4819-130-5-199903020-00015
[3] Xu H, et al. Effect of caffeine on ovariectomy-induced osteoporosis in rats. Biomed Pharmacother. 2019112:108650. DOI:10.1016/j.biopha.2019.108650

Raloxifene-d10(2512224-37-0)Related Product Information

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• Ropinirole-d14 HCl
• Roflumilast-d4
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• Rabeprazole-d4 Sodium Salt (benzimidazole-4,5,6,7-d4) 117976-90-6 unlabelled
• Ranitidine d6 HCl
• Ractopamine-d6 Hydrochloride
• 7,8-dimethyl-d6)
• 1-methyl-d3-propyl-1,2,2-d3) (mixture of diastereomers)