aphidicolin-17-monoacetate
aphidicolin-17-monoacetate Basic information
- Product Name:
- aphidicolin-17-monoacetate
- Synonyms:
-
- aphidicolin-17-monoacetate
- Aphidicolin 17-acetate
- 8,11a-Methano-11aH-cyclohepta[a]naphthalene-4,9-dimethanol, tetradecahydro-3,9-dihydroxy-4,11b-dimethyl-, 9-acetate, (3R,4R,4aR,6aS,8R,9R,11aS,11bS)-
- CAS:
- 51103-57-2
- MF:
- C22H36O5
- MW:
- 380.52
- Mol File:
- 51103-57-2.mol
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aphidicolin-17-monoacetate Usage And Synthesis
Uses
Aphidicolin 17-acetate is a selective eukaryotic DNA polymerase α inhibitor. Aphidicolin 17-acetate does not inhibit DNA polymerase β and γ. Aphidicolin 17-acetate markedly inhibits the in vivo DNA synthesis of sea urchin embryos and HeLa cells but not RNA and protein syntheses[1].
References
[1] Haraguchi T, et al. Specific inhibitors of eukaryotic DNA synthesis and DNA polymerase alpha, 3-deoxyaphidicolin and aphidicolin-17-monoacetate. Nucleic Acids Res. 1983 Feb 25;11(4):1197-209. DOI:10.1093/nar/11.4.1197
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