chinoin 123 Chemical Properties

Melting point:

154-155 °C(Solv: ethanol (64-17-5))

Boiling point:

472.0±55.0 °C(Predicted)

Density 

1.39±0.1 g/cm3(Predicted)

pka

4.45±0.10(Predicted)

chinoin 123 Usage And Synthesis

Originator

Acitemate ,Onbio Inc.

Manufacturing Process

23.6 g of 3-ethoxycarbonyl-7-methyl-4-oxo-6,7,8,9-tetrahydro-4Hpyrido[ 1,2a]pyrimidine and 10.0 g of glyoxylic acid monohydrate are reacted and the obtained 3-ethoxycarbonyl-7-methyl-9-carboxy(hydroxymethyl)-4- oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2a]pyrimidine is heated in 150 ml ethanol under stirring for 3 h. After cooling the crystals are filtered off and recrystallized from ethanol. Thus 3-ethoxycarbonyl-7-methyl-9- (carboxymethylene)-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2a]pyrimidine melting point 110°-112°C, is obtained (yield: 51%).
55.6 g of 3-ethoxycarbonyl-9-(carboxymethylene)-4-oxo-6,7,8,9-tetrahydro- 4H-pyrido[1,2a]pyrimidine are hydrogenated in 500 ml of ethanol in the presence of 20.0 g of 9% by weight Pd/C catalyst containing metal. When 1 mole of hydrogen has been used up, the catalyst is removed from the reaction mixture by filtration and the solution is evaporated under reduced pressure. The 3-ethoxycarbonyl-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidine-9- acetic acid is obtained (yield: 57%), melting point 156°-157°C (recrystallized from ethanol).

Therapeutic Function

Platelet aggregation inhibitor, Antihyperlipidemic

chinoin 123(64405-40-9)Related Product Information

• 5-Pyrimidinecarboxylic acid, 1,4-dihydro-4-oxo- (9CI)
• ETHYL 3-DI-N-PROPYLAMINOPROPIONATE
• 4-Hydroxypyrimidine-5-carboxylic acid methyl ester
• Ethyl 4-hydroxypyrimidine-5-carboxylate
• BUTYRAMIDINE
• 1-PIPERIDINEPROPIONIC ACID
• 3-ISOPROPYLAMINO-PROPIONIC ACID ETHYL ESTER X HCL >98%
• chinoin 123
• 6-ACRYLAMIDOHEXANOIC ACID
• 2-DIETHYLAMINOMETHYL-ACRYLIC ACID
• ETHYL 3-METHYL-1-PIPERIDINEPROPIONATE, 95
• METHYL 3-(PIPERIDIN-1-YL)PROPANOATE
• 2-PIPERIDIN-1-YLMETHYL-ACRYLIC ACID
• 3-(3-methylpiperidin-1-yl)propanoic acid
• 1-PIPERIDINEPROPIONIC ACID ETHYL ESTER
• 4-HYDROXY-2-METHYLPYRIMIDINE-5-CARBOXYLIC ACID
• 3-PIPERIDINE ACETIC ACID