Basic information Safety Supplier Related

E 2078

Basic information Safety Supplier Related

E 2078 Basic information

Product Name:
E 2078
Synonyms:
  • 66A-078
  • Methyl-L-Tyr-Gly-Gly-L-Phe-L-Leu-L-Arg-N2-methyl-L-Arg-D-Leu-NHEt
  • N-Methyl-L-Tyr-Gly-Gly-L-Phe-L-Leu-L-Arg-Nα-methyl-L-Arg-D-Leu-NHEt
  • (2R)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-3-(4-hydroxyphenyl)-2-(methylamino)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]pentanoyl]-met
  • 1-8-Dynorphin B (swine), N-methyl-7-(N2-methyl-L-arginine)-8-(N-ethyl-D-leucinamide)-
  • (N-Me-Tyr?,N-Me-Arg?,D-Leu-NHEt?)-Dynorphin A (1-8) trifluoroacetate salt
  • (N-Me-Tyr1,N-Me-Arg7,D-Leu-NHEt 8)-Dynorphin A (1-8) trifluoroacetate salt
  • (N-Me-Tyr1,N-Me-Arg7,D-Leu-NHEt8)-Dynorphin
CAS:
103613-84-9
MF:
C50H81N15O9
MW:
1036.27324
Mol File:
103613-84-9.mol
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E 2078 Chemical Properties

Density 
1.30±0.1 g/cm3(Predicted)
pka
9.99±0.15(Predicted)
Sequence
{Tyr(Me)}-Gly-Gly-Phe-Leu-Arg-{Arg(N-Me)}-{d-Leu}-{NHEt}
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E 2078 Usage And Synthesis

Uses

(N-Me-Tyr1,N-Me-Arg7,D-Leu-NHEt8)-Dynorphin A (1-8) (E-2078), a stable Dynorphin A (1–8) (HY-P2159) analog, is a kappa opioid receptor (KOR) agonist[1].

IC 50

κ Opioid Receptor/KOR

References

[1] Butelman ER, et al. Effects of E-2078, a stable dynorphin A(1-8) analog, on sedation and serum prolactin levels in rhesus monkeys. Psychopharmacology (Berl). 1999 Nov;147(1):73-80. DOI:10.1007/s002130051144

E 2078Supplier

Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Cellmano Biotech Limited
Tel
0551-65326643 18156095617
Email
info@cellmano.com
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Alabiotech Inc.
Tel
001-619-354-5251
Email
sales@alabiotech-e.com
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E 2078(103613-84-9)Related Product Information