5-hydroxyeicosatetraenoic acid lactone
5-hydroxyeicosatetraenoic acid lactone Basic information
- Product Name:
- 5-hydroxyeicosatetraenoic acid lactone
- Synonyms:
-
- 5-hydroxyeicosatetraenoic acid lactone
- 6-[(1E,3Z,6Z,9Z)-pentadeca-1,3,6,9-tetraenyl]oxan-2-one
- 2H-Pyran-2-one, tetrahydro-6-(1E,3Z,6Z,9Z)-1,3,6,9-pentadecatetraen-1-yl-
- CAS:
- 81517-87-5
- MF:
- C20H30O2
- MW:
- 302.45
- Mol File:
- 81517-87-5.mol
5-hydroxyeicosatetraenoic acid lactone Chemical Properties
- Boiling point:
- 445.7±34.0 °C(Predicted)
- Density
- 0.979±0.06 g/cm3(Predicted)
- solubility
- DMF: 50 mg/ml
DMSO: 50 mg/ml
Ethanol: 50 mg/mlPBS pH 7.2: 1 mg/ml - form
- Clear to light-yellow liquid.
5-hydroxyeicosatetraenoic acid lactone Usage And Synthesis
Uses
(±)5-HETE lactone is the racemate of 5-HETE lactone. 5-HETE lactone is a metabolite generated by a series of enzymatic reactions of arachidonic acid, and is also a substrate of paraoxonase-1 (PON1). 5-HETE lactone can be used in the study of B cell activation[1][2].
References
[1] Tao C, et al. Reactivity of tricarbonyl (pentadienyl) iron (1+) cations: enantioselective synthesis of 5-HETE methyl ester[J]. The Journal of Organic Chemistry, 1993, 58(8): 2134-2143.
[2] Picardo C M. The hydrolysis of 5-HETE lactone by paraoxonase 1 and its stability in serum[M]. 2007.
[3] F. A. J. KERDESKY. ChemInform Abstract: Synthesis and 5-Lipoxygenase Inhibitory Activity of 5-Hydroperoxy- 6,8,11,14-eicosatetraenoic Acid Analogues.[J]. ChemInform, 1987, 18 50. DOI: 10.1002/chin.198750355