3,6-Dichloro-4-methylpyridazine Chemical Properties

Melting point:

86-88 °C (lit.)

Boiling point:

149-151 °C/21 mmHg (lit.)

Density 

1.5462 (rough estimate)

refractive index 

1.6300 (estimate)

Flash point:

149-151°C/21mm

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

soluble in Methanol

pka

-0.56±0.10(Predicted)

form 

Crystalline Powder

color 

Brown

BRN 

119573

InChI

InChI=1S/C5H4Cl2N2/c1-3-2-4(6)8-9-5(3)7/h2H,1H3

InChIKey

ROYHWGZNGMXQEU-UHFFFAOYSA-N

SMILES

C1(Cl)=NN=C(Cl)C=C1C

CAS DataBase Reference

19064-64-3(CAS DataBase Reference)

NIST Chemistry Reference

Pyridazine, 3,6-dichloro-4-methyl-(19064-64-3)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-20/21/22

Safety Statements 

26-37/39-36/37/39-22

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

29339980

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

3,6-Dichloro-4-methylpyridazine Usage And Synthesis

Chemical Properties

Brown crystalline powder.

Uses

3,6-Dichloro-4-methylpyridazine has been used in the synthesis of 7-methyl-2-phenylimidazo[1,2-b]pyridazine-3-carboxylic acid.

Application

3,6-Dichloro-4-methylpyridazine is mainly used as an intermediate in pesticides and pharmaceuticals.

Hazard

3,6-Dichloro-4-methylpyridazine causes skin irritation and serious eye irritation, it may cause respiratory irritation.

Synthesis

4-Methyl-1,2-dihydropyridazine-3,6-dione (9.48 g, 75.2 mmol) was suspended in phosphoryl chloride (70 mL, 750 mmol) under nitrogen protection and stirred at room temperature. Subsequently, the reaction mixture was heated to a mild reflux condition and maintained for 4 hours until a golden yellow homogeneous solution was formed. Upon completion of the reaction, the mixture was cooled and the excess trichlorophosphorus was removed by distillation under reduced pressure (14 mbar, 50-70°C). The resulting viscous brown oil was slowly added dropwise to an ice-cooled saturated sodium bicarbonate solution (200 mL) while stirring vigorously. The pH of the mixture was adjusted to 6 by batchwise addition of solid sodium bicarbonate, followed by extraction with ethyl acetate (2 x 60 mL). The organic phases were combined, washed with saturated sodium bicarbonate solution (30 mL), dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to afford 3,6-dichloro-4-methylpyridazine (11.5 g, 70.8 mmol, 94% yield) as a yellow powder. The product was recrystallized from light petroleum ether/ether and had a melting point of 87-88°C. IR spectrum (KBr, cm^-1): 3054, 1567, 1434, 1351, 1326, 1145, 1121, 914, 720. NMR hydrogen spectrum (200 MHz, CDCl3): δ 2.42 (3H, d, J = 1.0 Hz), 7.41 ( 1H, q, J = 0.9 Hz). NMR carbon spectrum (50 MHz, CDCl3): δ 19.2 (CH3), 130.1 (CH-5), 140.7 (C-4), 155.6 (C-6), 157.3 (C-3). Low resolution mass spectrum (EI): m/z 162 ([M+]). Calculated elemental analysis (C5H4Cl2N2): C, 36.84; H, 2.47; N, 17.19. Measured values: C, 36.93; H, 2.57; N, 17.48.

References

[1] Bioorganic and Medicinal Chemistry, 2012, vol. 20, # 5, p. 1644 - 1658
[2] Journal of the American Chemical Society, 1954, vol. 76, p. 2201
[3] Pharmaceutical Bulletin, 1957, vol. 5, p. 587,588
[4] Helvetica Chimica Acta, 1954, vol. 37, p. 121,131
[5] Journal of the American Chemical Society, 1954, vol. 76, p. 4454,4457

3,6-Dichloro-4-methylpyridazine(19064-64-3)Related Product Information

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• 4-(TERT-BUTOXYCARBONYL)PHENYLBORONIC ACID
• 6-Chloro-5-fluoro-7-azaindole
• 5-FLUORO-1H-PYRROLO[2,3-B]PYRIDINE
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• 1H-Pyrrolo[2,3-b]pyridine, 3-bromo-1-[(4-methylphenyl)sulfonyl]-
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