7-BROMO-1-BENZOFURAN-2-CARBOXYLICACID Chemical Properties

Boiling point:

370.9±22.0 °C(Predicted)

Density 

1.784±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

pka

2.90±0.30(Predicted)

Appearance

Off-white to light yellow Solid

CAS DataBase Reference

550998-59-9

Safety Information

HS Code 

2933399990

7-BROMO-1-BENZOFURAN-2-CARBOXYLICACID Usage And Synthesis

Application

7-Bromobenzofuran-2-carboxylic acid can be used as a pharmaceutical synthesis intermediate.

Synthesis

Method 1, two-step synthesis. 1) Preparation of 3-bromo-2-hydroxybenzaldehyde: 2-Bromophenol is heated under reflux with anhydrous magnesium chloride, paraformaldehyde, and triethylamine in acetonitrile. Work-up yields the product. 2) Preparation of 7-bromobenzofuran-2-carboxylic acid: The product from step 1 (crude) is heated with methyl chloroacetate, tetra-n-butylammonium iodide, and potassium carbonate. Water and THF are then added, followed by potassium hydroxide, and the mixture is stirred at room temperature overnight. Subsequent acidification and extraction/purification yield the product.

7-BROMO-1-BENZOFURAN-2-CARBOXYLICACID(550998-59-9)Related Product Information

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