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FENOBAM

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FENOBAM Basic information

Product Name:
FENOBAM
Synonyms:
  • FENOBAM
  • 1-(3-Chlorophenyl)-3-(4,5-dihydro-1-methyl-4-oxo-1H-imidazol-2-yl)urea
  • Mcn-3377
  • N-(3-CHLOROPHENYL)-N'-(4,5-DIHYDRO-1-METHYL-4-OXO-1H-IMIDAZOL-2-YL)UREA
  • N-(3-CHLOROPHENYL)-N'-(4,5-DIHYDRO-1-METHYL-4-OXO-1H-IMIDAZOLE-2-YL)UREA
  • Urea, N-(3-chlorophenyl)-N'-(4,5-dihydro-1-methyl-4-oxo-1H-imidazol-2-yl)-
  • Fenobam,anxiolytic,brain-penetrant,mGluR,nonbenzodiazepine,Inhibitor,addiction,inhibit,cocaine,Metabotropic glutamate receptors
  • 1-(3-Chlorophenyl)-3-(1-methyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl)urea
CAS:
57653-26-6
MF:
C11H11ClN4O2
MW:
266.68
Product Categories:
  • Glutamate receptor
  • Glutamate
Mol File:
57653-26-6.mol
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FENOBAM Chemical Properties

Density 
1.47±0.1 g/cm3(Predicted)
storage temp. 
Store at RT
solubility 
DMSO: >20mg/mL
form 
solid
pka
8.32±0.20(Predicted)
color 
white
InChI
1S/C11H11ClN4O2/c1-16-6-9(17)14-10(16)15-11(18)13-8-4-2-3-7(12)5-8/h2-5H,6H2,1H3,(H2,13,14,15,17,18)
InChIKey
DWPQODZAOSWNHB-UHFFFAOYSA-N
SMILES
CN1CC(=O)N=C1NC(=O)Nc2cccc(Cl)c2
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Safety Information

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
Storage Class
11 - Combustible Solids
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FENOBAM Usage And Synthesis

Uses

Sedative-hypnotic.

Uses

Fenobam is a potent and selective non-competitive mGluR5 antagonist.

Biological Activity

Primary Target
mGlu6 receptors', 'Target Ki: 54 nM and 31 nM at recombinant mGlu6 receptors of r at and human, respectively

in vivo

Fenobam (30-60 mg/kg; p.o.; 3 times a week) significantly inhibits self-administration behavior in rats[3].

Animal Model:Male Long-Evans rats (250-300 g)[3].
Dosage:30-60 mg/kg
Administration:Oral administration; 3 times a week.
Result:Inhibited self-administration.

IC 50

mGluR5: 84 nM (IC50); rat mGluR5: 54 nM (Kd); human mGluR5: 31 nM (Kd)

storage

Room temperature

FENOBAMSupplier

J & K SCIENTIFIC LTD.
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3B Pharmachem (Wuhan) International Co.,Ltd.
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821-50328103-801 18930552037
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3bsc@sina.com
Ascent Scientific
Tel
4401179829988
Email
customerservice@ascentscientific.co.uk
LGM Pharma
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1-(800)-881-8210
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inquiries@lgmpharma.com
Bide Pharmatech Ltd.
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400-400-164-7117 18317119277
Email
product02@bidepharm.com
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