FENOBAM
FENOBAM Basic information
- Product Name:
- FENOBAM
- Synonyms:
-
- FENOBAM
- 1-(3-Chlorophenyl)-3-(4,5-dihydro-1-methyl-4-oxo-1H-imidazol-2-yl)urea
- Mcn-3377
- N-(3-CHLOROPHENYL)-N'-(4,5-DIHYDRO-1-METHYL-4-OXO-1H-IMIDAZOL-2-YL)UREA
- N-(3-CHLOROPHENYL)-N'-(4,5-DIHYDRO-1-METHYL-4-OXO-1H-IMIDAZOLE-2-YL)UREA
- Urea, N-(3-chlorophenyl)-N'-(4,5-dihydro-1-methyl-4-oxo-1H-imidazol-2-yl)-
- Fenobam,anxiolytic,brain-penetrant,mGluR,nonbenzodiazepine,Inhibitor,addiction,inhibit,cocaine,Metabotropic glutamate receptors
- 1-(3-Chlorophenyl)-3-(1-methyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl)urea
- CAS:
- 57653-26-6
- MF:
- C11H11ClN4O2
- MW:
- 266.68
- Product Categories:
-
- Glutamate receptor
- Glutamate
- Mol File:
- 57653-26-6.mol
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FENOBAM Chemical Properties
- Density
- 1.47±0.1 g/cm3(Predicted)
- storage temp.
- Store at RT
- solubility
- DMSO: >20mg/mL
- pka
- 8.32±0.20(Predicted)
- form
- solid
- color
- white
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FENOBAM Usage And Synthesis
Uses
Sedative-hypnotic.
Uses
Fenobam is a potent and selective non-competitive mGluR5 antagonist.
Biological Activity
Primary Target
mGlu6 receptors', 'Target Ki: 54 nM and 31 nM at recombinant mGlu6 receptors of r at and human, respectively
in vivo
Fenobam (30-60 mg/kg; p.o.; 3 times a week) significantly inhibits self-administration behavior in rats[3].
| Animal Model: | Male Long-Evans rats (250-300 g)[3]. |
| Dosage: | 30-60 mg/kg |
| Administration: | Oral administration; 3 times a week. |
| Result: | Inhibited self-administration. |
IC 50
mGluR5: 84 nM (IC50); rat mGluR5: 54 nM (Kd); human mGluR5: 31 nM (Kd)
storage
Room temperature
FENOBAMSupplier
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