3-[(2-METHYL-1,3-THIAZOL-4-YL)ETHYNYL]PYRIDINE
3-[(2-METHYL-1,3-THIAZOL-4-YL)ETHYNYL]PYRIDINE Basic information
- Product Name:
- 3-[(2-METHYL-1,3-THIAZOL-4-YL)ETHYNYL]PYRIDINE
- Synonyms:
-
- 3-[(2-METHYL-1,3-THIAZOL-4-YL)ETHYNYL]PYRIDINE
- MTEP
- 3-(2-Methyl-thiazol-4-ylethynyl)-pyridine
- 2-methyl-4-(pyridin-3-ylethynyl)thiazole
- 3-[2-(2-Methyl-1,3-thiazol-4-yl)ethynyl]pyridine
- 2-methyl-4-(2-pyridin-3-ylethynyl)-1,3-thiazole
- Pyridine, 3-[(2-methyl-4-thiazolyl)ethynyl]-
- MTEP hydrochloride >=98% (HPLC)
- CAS:
- 329205-68-7
- MF:
- C11H8N2S
- MW:
- 200.26
- Mol File:
- Mol File
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3-[(2-METHYL-1,3-THIAZOL-4-YL)ETHYNYL]PYRIDINE Chemical Properties
- Boiling point:
- 360.7±17.0 °C(Predicted)
- Density
- 1.26±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- methanol: 1mg/mL
DMSO: 5mg/mL - pka
- 3.41±0.12(Predicted)
- form
- White to yellow solid.
- color
- white to yellow
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3-[(2-METHYL-1,3-THIAZOL-4-YL)ETHYNYL]PYRIDINE Usage And Synthesis
Uses
MTEP Hydrochloride is a potent mGlu5 receptor antagonist, acting as a negative allosteric modulator.
Biological Activity
Cell permeable: yes', 'Primary Target
mGluR5', 'Product does not compete with ATP.', 'Reversible: no', 'Target IC50: 5 nM in Ca2+-flux assay', 'Target Ki: 16 nM for mGluR5 (metabotropic glutamate receptor subtype-5)
in vivo
MTEP (0-5 mg/kg, i.p., once) inhibits the catalepsy induced by Haloperidol (HY-14538) (0.5 mg/kg/2 ml i.p.)[2].
MTEP (0.3-3 mg/kg, intraperitoneal injection, once) induces antidepressant-like effects in male C57BL/6J mice[3].
| Animal Model: | Male Wistar rats (215-315 g, 5-9/group)[2] |
| Dosage: | 1, 3 and 5 mg/kg |
| Administration: | IP, once, injected 60 min after Haloperidol (HY-14538) (0.5 mg/kg/2 ml i.p.) |
| Result: | Inhibited the catalepsy induced by Haloperidol (HY-14538). |
| Animal Model: | Male C57BL/6J mice (23-25 g)[3] |
| Dosage: | 0.3, 1 and 3 mg/kg |
| Administration: | IP, 1 h before the test |
| Result: | Significantly decreased the immobility time of mice in the tail suspension test (TST) by 24%, 41% and 48%, respectively. The efficacy of MTEP used at doses of 1 and 3 mg/kg was not significantly different from that of Imipramine (HY-B1490A) (20 mg/kg, ip), used as a positive standard. |
IC 50
mGluR5: 5 nM (IC50); mGluR5: 16 nM (Ki)
3-[(2-METHYL-1,3-THIAZOL-4-YL)ETHYNYL]PYRIDINESupplier
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