(2-fluoro-4-nitrophenyl)methanol Chemical Properties

Melting point:

103-105℃

Boiling point:

319.9±27.0 °C(Predicted)

Density 

1.434±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

13.14±0.10(Predicted)

form 

Solid

color 

White to yellow

CAS DataBase Reference

660432-43-9

Safety Information

HazardClass 

IRRITANT

HS Code 

2906290090

(2-fluoro-4-nitrophenyl)methanol Usage And Synthesis

Synthesis

General procedure for the synthesis of 2-fluoro-4-nitrobenzyl alcohol from 2-fluoro-4-nitrobenzaldehyde: To a solution of 2-fluoro-4-nitrobenzaldehyde (1.0 g, 5.92 mmol) in methanol (10 mL) was slowly added sodium borohydride (814 mg, 22 mmol). The reaction mixture was stirred at room temperature for 15 min and then concentrated by rotary evaporator. The concentrated residue was subjected to liquid-liquid partitioning with ethyl acetate (100 mL) and saturated aqueous sodium chloride solution (100 mL). The combined organic phases were washed with saturated aqueous sodium chloride solution (100 mL x 2) and dried with anhydrous sodium sulfate. After filtration, the filtrate was concentrated to give the red solid product 2-fluoro-4-nitrobenzyl alcohol (1.0 g, 99% yield).

References

[1] Patent: TWI602818, 2017, B. Location in patent: Paragraph 0481; 0482
[2] Patent: WO2014/173289, 2014, A1. Location in patent: Paragraph 0479; 0481; 0482

(2-fluoro-4-nitrophenyl)methanol(660432-43-9)Related Product Information

• 2-FLUORO-4-METHOXYBENZYL ALCOHOL
• Benzenemethanol, 2-fluoro-4-methyl- (9CI)
• (2-Iodo-4-nitro-phenyl)-methanol
• 1-(Bromomethyl)-2-chloro-3-methoxybenzene
• (2-Chloro-3-methoxyphenyl)methanol
• 2-bromo-6-chloro-4-fluorobenzylbromide
• 3-Bromo-4-hydroxymethyl-phenol
• (2-Fluoro-6-methylphenyl)methanol, (6-Fluoro-o-tolyl)methanol
• 2-FLUORO-5-METHYLBENZYL BROMIDE
• 2-Bromo-3,6-difluorobenzyl bromide
• 2-Iodo-4-nitrobenzyl Bromide
• 2-Bromo-3,6-difluorobenzyl alcohol
• 3-Nitrobenzyl alcohol
• 4-nitrobenzyl alcohol