[[4-[[2-(1-Methylethoxy)ethoxy]methyl]phenoxy]methyl]oxirane Chemical Properties

Boiling point:

362.6±22.0 °C(Predicted)

Density 

1.084±0.06 g/cm3(Predicted)

storage temp. 

Refrigerator

solubility 

Chloroform (Slightly), Methanol (Sparingly)

form 

Oil

color 

Colourless

CAS DataBase Reference

66722-57-4

[[4-[[2-(1-Methylethoxy)ethoxy]methyl]phenoxy]methyl]oxirane Usage And Synthesis

Chemical Properties

Pale Yellow Oil

Uses

An intermediate for the synthesis of Bisoprolol.

Synthesis

The synthesis of 4-[[2-(1-Methylethoxy)ethoxy]methyl]phenoxy]methyl]oxirane is as follows: steps. 1) Preparation of 4-hydroxybenzyl alcohol: 4-Hydroxybenzaldehyde is reduced with NaBH4. Work-up yields the product. 2) Preparation of 4-[(2-isopropoxyethoxy)methyl]phenol: 4-Hydroxybenzyl alcohol reacts with 2-isopropoxyethanol catalyzed by Amberlyst-15 resin. Work-up gives the product. 3) Preparation of the title oxirane derivative: The sodium salt of the phenol from step 2 reacts with epichlorohydrin. Toluene extraction is performed. The organic phase is treated with solid NaOH, washed, and distilled to an oil. High-vacuum distillation purifies the product.

[[4-[[2-(1-Methylethoxy)ethoxy]methyl]phenoxy]methyl]oxirane(66722-57-4)Related Product Information

• 2-P-TOLYLOXYMETHYL-OXIRANE
• Bisoprolol Impurity 9
• 4-Isopropoxyethoxymethylphenol
• Bisoprolol Impurity 7
• WIXOVOWSUCEDGS-UHFFFAOYSA-N
• N-(2-hydroxy-3-(4-((2-isopropoxyethoxy)methyl)phenoxy)propyl) -N-isopropylformamide
• 4-Oxiranylmethoxy-benzaldehyde
• Bisoprolol fumarate
• Bisoprolol EP Impurity J
• Dehydroxy Bisoprolol
• H 128/80
• 4-Hydroxybenzaldehyde
• p-(2,3-Epoxypropoxy)benzyl Alcohol
• Des(isopropoxyethyl) Bisoprolol
• Ganciclovir Monoproprionate
• Keto Bisoprolol
• Bisoprolol EP Impurity C
• 1-(Isopropylamino)-3-(4-methylphenoxy)propane-2-ol