[2-(aminomethyl)phenyl]methanol Chemical Properties

Boiling point:

271℃

Density 

1.113

Flash point:

118℃

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

pka

14.28±0.10(Predicted)

[2-(aminomethyl)phenyl]methanol Usage And Synthesis

Uses

[2-(aminomethyl)phenyl]methanol can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.

Uses

(2-(Aminomethyl)phenyl)methanol is a useful research intermediate for the total synthesis of Adalinine.

Synthesis

(4-Aminomethyl-phenyl)-methanol hydrochloride salt 4-Hydroxymethyl-benzonitrile (2.0 g, 15 mol) was reduced using Raney nickel (0. 5g) and hydrogen (50 psi) in MeOH: NH3 (100ml) for 20 hours. The reaction mixture was filtered through a pad of celite. The filtrate was concentrated under reduced pressure to afford (4-aminomethyl-phenyl)-methanol hydrochloride salt (2.01 g, 98percent) as a white solid of sufficient purity for use without further purification: MS (APCI+) : m/z 138.3 (M+H).

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