2-Bromo-5-chlorobenzotrifluoride Chemical Properties

Melting point:

18-20°C

Boiling point:

179-180 °C (lit.)

Density 

1.759 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.5080(lit.)

Flash point:

198°C

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

form 

clear liquid

color 

Colorless to Almost colorless

BRN 

2448030

CAS DataBase Reference

344-65-0(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39-36-37-23

WGK Germany 

3

Hazard Note 

Irritant

HS Code 

29039990

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

2-Bromo-5-chlorobenzotrifluoride Usage And Synthesis

Chemical Properties

Clear colourless to slightly yellow liquid

Uses

2-Bromo-5-chlorobenzotrifluoride was used in preparation of 6-[4-chloro-2-(trifluoromethyl)phenyl]-3-fluoro-2-methylpyridine and 4,4′-dichloro-2,2′-bis(trifluoromethyl) diphenyl sulphone.

Synthesis

The general procedure for synthesizing 2-bromo-5-chlorobenzotrifluoride from 5-amino-2-bromobenzotrifluoride was as follows: a diazonium salt solution was prepared according to the method described in Example 3. The cooled diazonium salt solution was slowly added to a pre-stirred and cooled mixture of CuCl (8.9 g, 0.091 mol) dissolved in concentrated hydrochloric acid (46 g, 0.44 mol). The reaction system was kept at a low temperature and when the addition was completed, it was gradually warmed up to room temperature with continuous stirring for 2 to 3 hours. Subsequently, the reaction mixture was heated to 60-70 °C to ensure complete reaction. Upon completion of the reaction, the target product 2-bromo-5-chlorobenzotrifluoride was obtained by isolation by appropriate methods. Yield: 65%.

References

[1] Patent: WO2016/63300, 2016, A1. Location in patent: Page/Page column 8
[2] Journal of the American Chemical Society, 1953, vol. 75, p. 3034

2-Bromo-5-chlorobenzotrifluoride(344-65-0)Related Product Information

• 3-Chlorobenzotrifluoride
• 2-Fluoro-5-bromobenzotrifluoride
• Benzotrifluoride
• 3-BROMO-4-CHLOROBENZOTRIFLUORIDE
• 4-AMINO-3-BROMO-5-CHLOROBENZOTRIFLUORIDE
• 3-BROMO-2-CHLOROBENZOTRIFLUORIDE
• 2-Bromo-5-chlorobenzotrifluoride
• 4-Bromochlorobenzene
• 1-Bromo-4-chloro-2-methylbenzene
• 3-BROMO-6-CHLOROBENZOTRIFLUORIDE,5-BROMO-2-CHLOROBENZOTRIFLUORIDE
• 2-BROMO-6-CHLOROBENZOTRIFLUORIDE
• 4-BROMO-3-CHLOROBENZOTRIFLUORIDE
• 2-AMINO-3-BROMO-5-CHLOROBENZOTRIFLUORIDE
• 1-Bromo-2-difluoromethylbenzene
• 2,3-Dibromo-5-chlorobenzotrifluoride
• 2-BROMO-3-CHLOROBENZOTRIFLUORIDE
• 2-AMINO-5-BROMO-3-CHLOROBENZOTRIFLUORIDE
• 4-BROMO-2-CHLOROBENZOTRIFLUORIDE