3-ETHOXYACRYLIC ACID Chemical Properties

Melting point:

109 °C

Boiling point:

70-140 °C(Press: 1 Torr)

Density 

1.1100 g/cm3

storage temp. 

2-8°C

form 

solid

pka

4.86±0.10(Predicted)

Appearance

Off-white to light yellow Solid

CAS DataBase Reference

6192-01-4

Safety Information

Hazard Codes 

C,Xi

Risk Statements 

36

Safety Statements 

26

HS Code 

2916120090

3-ETHOXYACRYLIC ACID Usage And Synthesis

Synthesis Reference(s)

Synthesis, p. 1016, 1986 DOI: 10.1055/s-1986-31854

Synthesis

General procedure: ethyl (E)-3-ethoxyacrylate (5.0 g, 0.035 mol) was dissolved in 2 M aqueous sodium hydroxide solution (40 mL) and the reaction was refluxed for 4 hours. Upon completion of the reaction, the mixture was cooled to room temperature and the pH was adjusted to 3 with 4 M aqueous hydrochloric acid, followed by extraction with ethyl acetate. The organic phase was decolorized by activated carbon and dried over anhydrous sodium sulfate, then filtered and concentrated to dryness under reduced pressure to afford 3-ethoxyacrylic acid as a brown solid (1.8 g, 44% yield).

References

[1] Patent: WO2017/100668, 2017, A1. Location in patent: Page/Page column 334
[2] Patent: WO2018/103058, 2018, A1. Location in patent: Page/Page column 333
[3] Journal of the Chemical Society, 1958, p. 153,155

3-ETHOXYACRYLIC ACID(6192-01-4)Related Product Information

• VERBENALIN
• Oleuropein
• Diethyl ethoxymethylenemalonate
• GARDENOSIDE
• 3-ETHOXYACRYLIC ACID ETHYL ESTER,BETA-ETHOXYACRYLIC ACID ETHYL ESTER
• Methyl isodehydroacetate
• ETHYL 3-AMINO-3-ETHOXYACRYLATE HYDROCHLORIDE
• Geniposide
• LOGANIC ACID
• 2-CYANO-3-ETHOXYACRYLIC ACID ETHYL ESTER
• Methyl coumalate
• 4-ETHOXYMETHYLENE-2-PHENYL-2-OXAZOLIN-5-ONE
• ISODEHYDROACETIC ACID
• Coumalic acid
• 5-Carbethoxy-4,6-dimethyl-2-pyrone
• Ethyl 3,3-diethoxyacrylate
• SHANZHISIDE METHYL ESTER
• 2-cyano-3-ethoxyacrylic acid