Propargylglycine Chemical Properties

Melting point:

243 °C (decomp)

Boiling point:

273.5±20.0 °C(Predicted)

Density 

1.150±0.06 g/cm3(Predicted)

pka

2.18±0.10(Predicted)

form 

Solid

color 

Off-white to light yellow

InChI

InChI=1S/C5H7NO2/c1-2-3-6-4-5(7)8/h1,6H,3-4H2,(H,7,8)

InChIKey

XSJLQGMTIHCDSS-UHFFFAOYSA-N

SMILES

C(O)(=O)CNCC#C

Propargylglycine Usage And Synthesis

Uses

N-Propargylglycine is an orally active irreversible inhibitor of proline dehydrogenase (PRODH). N-Propargylglycine has antitumor activity and can be used in the study of neurodegenerative diseases[1].

References

[1] Scott GK, et al. N-Propargylglycine: a unique suicide inhibitor of proline dehydrogenase with anticancer activity and brain-enhancing mitohormesis properties. Amino Acids. 2021 Dec;53(12):1927-1939. DOI:10.1007/s00726-021-03012-9