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Cephalomannine

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Cephalomannine Basic information

Product Name:
Cephalomannine
Synonyms:
  • TAXOL B
  • BENZENEPROPANOICACID,ALPHA-HYDROXY-BETA-[(2-METHYL-1-OXO-2-BUTENYL)AMINO]-,6,12B-BIS(ACETYLOXY)-12-(BENZOYLOXY)-2A,3,4,4A,5,6,9,10,11,12,12A,12B-DODECAHYDRO-4,11-DIHYDROXY-4A,8,13,13-TETRAMETHYL-5-OXO-7,11-METHANO-1H-CYCLODECA[3,4]BENZ[1,2-
  • BENZENEPROPANOIC ACID, ALPHA-HYDROXY-BETA-[(2-METHYL-1-OXO-2-BUTENYL)AMINO]-,6,12B-BIS(ACETYLOXY)-12-(BENZOYLOXY)-2A,3,4,4A,5,6,9,10,11,12,12A,12B-DODECAHYDRO-4,11-DIHYDROXY-4A,8,13,13-TETRAMETHYL-5-OXO-7,11-METHANO-1H-CYCLODECA[3,4]BENZ[1,2-B]OXET-9-YL ESTER,[2AR-[2A,4,4A,6,9[R*,S*(E)],11,12,12A,12B]]-
  • CEPHALOMANNINE
  • paclitaxel iMpurity I
  • CephaloMannine, froM Taxus chinensis
  • (αR,βS)-α-Hydroxy-β-[[(2E)-2-Methyl-1-oxo-2-buten-1-yl]aMino]benzenepropanoic Acid (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)- 12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetraMethyl-5-oxo-7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl Ester
  • NSC 318735
CAS:
71610-00-9
MF:
C45H53NO14
MW:
831.9
Product Categories:
  • Inhibitors
  • Alkaloids
  • Antineoplastic and Immunosuppressive AntibioticsEnzyme Inhibitors by Enzyme
  • DNA polymerase - alphaAntibiotics
  • Antibiotics
  • Antibiotics A to
  • Antibiotics A-FAntibiotics
  • Antibiotics by Application
  • Chemical Structure Class
  • D to
  • Interferes with DNA SynthesisAntibiotics
  • Mechanism of Action
  • Penicillins and Cephalosporins (beta-Lactams)
  • Herb extract
  • Chiral Reagents
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • Impurities
Mol File:
71610-00-9.mol
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Cephalomannine Chemical Properties

Melting point:
139-141?C
Boiling point:
929.5±65.0 °C(Predicted)
Density 
1.36±0.1 g/cm3(Predicted)
storage temp. 
-20°C Freezer
solubility 
DMSO: 14 mg/mL, soluble
form 
solid
pka
11.95±0.20(Predicted)
color 
White to Pale Beige
InChIKey
DBXFAPJCZABTDR-WBYYIXQISA-N
CAS DataBase Reference
71610-00-9
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Safety Information

Hazard Codes 
Xi
Risk Statements 
37/38-41
Safety Statements 
26-39
WGK Germany 
3
HS Code 
29329990

MSDS

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Cephalomannine Usage And Synthesis

Chemical Properties

Off-White Solid

Occurrence

A taxane derivative, cephalomannine occurs in the extract of Cephalotaxus rnannii. It has been obtained as colourless needles from MeOH aq. and is laevorotatory with a specific rotation of [α]D -41° (MeOH).

Uses

Cephalomannine is an active anti-cancer agent obtained from Taxus yunnanensis and has an antineoplastic effect on tumors found in mice. Cephalomannine is a chemotherapy drug that is given as a treatment for some types of cancer. Cephalomannine is most com

Uses

Antitumor, antiproliferative.

Uses

similar anti-cancer function as Taxol

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