5-PHENYLPICOLINIC ACID Chemical Properties

Melting point:

156-157℃

Boiling point:

399℃

Density 

1.241

Flash point:

195℃

storage temp. 

2-8°C

form 

solid

pka

0.95±0.50(Predicted)

color 

White

CAS DataBase Reference

75754-04-0

Safety Information

Risk Statements 

22-36/37/38

Safety Statements 

22-26-36/37/39

HS Code 

2933399990

5-PHENYLPICOLINIC ACID Usage And Synthesis

Synthesis

Methyl 5-phenylpyridinecarboxylate (120 mg) was used as a raw material and dissolved in a solvent mixture of tetrahydrofuran (5 mL) and water (5 mL). Lithium hydroxide (100 mg) was added to the solution and the reaction mixture was stirred for 16 hours at room temperature. Upon completion of the reaction, water was added to the reaction solution and extracted with ethyl acetate. The aqueous layer was separated, its pH was adjusted to 6 with hydrochloric acid and extracted again with ethyl acetate. The organic layers were combined, washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was removed by distillation under reduced pressure to give 100 mg of 5-phenylpyridinecarboxylic acid in 89% yield.

References

[1] Patent: JP2017/171619, 2017, A. Location in patent: Paragraph 0103; 0107
[2] Journal of Medicinal Chemistry, 2011, vol. 54, # 13, p. 4721 - 4734

5-PHENYLPICOLINIC ACID(75754-04-0)Related Product Information

• Pyridine
• 5-PHENYLPYRIDINE-2-CARBONITRILE
• Chromium picolinate
• 2-Picolinic acid
• 3-PHENYLPICOLINIC ACID
• 4-PHENYLPICOLINIC ACID
• 6-PHENYLPICOLINIC ACID
• 5-PHENYLPICOLINIC ACID
• 2-METHYL-5-PHENYLPYRIDINE
• 5-(4-Fluorophenyl)pyridine-2-carboxylic acid
• 5-PHENYLPYRIDINE-2-CARBALDEHYDE