TCS 46B
TCS 46B Basic information
- Product Name:
- TCS 46B
- Synonyms:
-
- TCS 46B
- 1,3-Dihydro-5-[3-[4-(phenylmethyl)-1-2H-benzimidazol-2-one
- 2H-Benzimidazol-2-one, 1,3-dihydro-5-[3-[4-(phenylmethyl)-1-piperidinyl]-1-propyn-1-yl]-
- CAS:
- 302799-86-6
- MF:
- C22H23N3O
- MW:
- 345.44
- Mol File:
- 302799-86-6.mol
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TCS 46B Chemical Properties
- Boiling point:
- 440.4±38.0 °C(Predicted)
- Density
- 1.24±0.1 g/cm3(Predicted)
- storage temp.
- Store at RT
- solubility
- Soluble to 100 mM in DMSO and to 100 mM in ethanol
- form
- Powder
- pka
- 11.51±0.30(Predicted)
- color
- Off-white to light yellow
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TCS 46B Usage And Synthesis
Uses
TCS 46b is a subtype-selective NR1A/NR2B NMDA receptor antagonist.
Biological Activity
Orally active, subtype-selective NR1A/NR2B NMDA receptor antagonist (IC 50 values are 5.3, 35000 and > 100000 nM for NR1A/2B, NR1A/2A and NR1A/2C receptor subtypes respectively). Potentiates the effect of L-DOPA in 6-OHDA-lesioned rats following oral administration.
TCS 46BSupplier
3B Pharmachem (Wuhan) International Co.,Ltd.
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- 821-50328103-801 18930552037
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Shanghai Lollane Biological Technology Co.,Ltd.
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- 021-52996696，15000506266 15000506266
EMMX Biotechnology LLC
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- 888-539-0666
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ShangHai Biochempartner Co.,Ltd
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- 177-54423994 17754423994
- 2853530910@QQ.com
Shanghai Chaolan Chemical Technology Center
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- 021-QQ：65489617 15618227136
- Sales@ATKchemical.com