(1S,2S)-1-(4-HYDROXYPHENYL)-2-(4-HYDROXY-4-PHENYLPIPERIDINO)-1-PROPANOL
(1S,2S)-1-(4-HYDROXYPHENYL)-2-(4-HYDROXY-4-PHENYLPIPERIDINO)-1-PROPANOL Basic information
- Product Name:
- (1S,2S)-1-(4-HYDROXYPHENYL)-2-(4-HYDROXY-4-PHENYLPIPERIDINO)-1-PROPANOL
- Synonyms:
-
- 1-((1S,2S)
- -1-Hydroxy-1-(4-hydroxyphenyl)
- propan-2-yl)
- (1S,2S)-1-(4-HYDROXYPHENYL)-2-(4-HYDROXY-4-PHENYLPIPERIDINO)-1-PROPANOL
- CP 101606
- 1-[(1S,2S)-2-Hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]-4-phenylpiperidin-4-ol
- (1s,2s)-1-[4-[ hydroxylphenyl]- 2- ( 4-hydroxy-4-pheny1piperidino)-1- propanol
- 1-((1S,2S)-1-Hydroxy-1-(4-hydroxyphenyl)propan-2-yl)-4-phenylpiperidin-4-ol
- CAS:
- 134234-12-1
- MF:
- C20H25NO3
- MW:
- 327.42
- Mol File:
- 134234-12-1.mol
(1S,2S)-1-(4-HYDROXYPHENYL)-2-(4-HYDROXY-4-PHENYLPIPERIDINO)-1-PROPANOL Chemical Properties
- Boiling point:
- 534.4±50.0 °C(Predicted)
- Density
- 1.228
- storage temp.
- 2-8°C
- solubility
- DMSO: ≥35mg/mL
- pka
- 9.99±0.26(Predicted)
- form
- powder
- color
- white to tan
- optical activity
- [α]/D +50 to +60° (c=1, MeOH)
(1S,2S)-1-(4-HYDROXYPHENYL)-2-(4-HYDROXY-4-PHENYLPIPERIDINO)-1-PROPANOL Usage And Synthesis
Uses
Traxoprodil (CP101,606) is a potent and selective NMDA antagonist and protect hippocampal neurons with an IC50 of 10 nM.
Uses
CP-101,606 has been used as a N-methyl-D-aspartate (NMDA)?receptor antagonist to study its role in recovery of spinal cord injuries.
brand name
Traxoprodil is INN.
General Description
CP-101,606 (Traxoprodil) is a substituted 4-phenylpiperidine and is localized in the fore brain neurons.
Biochem/physiol Actions
Traxoprodil (CP-101,606) is a potent noncompetitive antagonist of N-methyl-D-aspartate (NMDA) receptors, selective for the NR2B subunit. It has been shown to be neuroprotective in animal models of brain injury and stroke.
in vivo
Traxoprodil is potent at blocking haloperidol-induced catalepsy and with an ED50 less than 1 mg/kg. Traxoprodil is effective at 1 mg/kg to block NMDA (ip) stimulated cfos induction in mice[1]. Traxoprodil at a dose of 20 and 40 mg/kg exhibits antidepressant activity in the Forced swim test and it is not related to changes in animals’ locomotor activity[2]. Traxoprodil (20 nM i.c.v.) increases the latency to generalized tonic-clonic seizures induced by PTZ (70 mg/kg; i.p.). Traxoprodil (60 mg/kg, p.o.) increases the latency to clonic and generalized seizures, and decreases the total time spent in seizures[3].
IC 50
NMDA Receptor
(1S,2S)-1-(4-HYDROXYPHENYL)-2-(4-HYDROXY-4-PHENYLPIPERIDINO)-1-PROPANOLSupplier
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(1S,2S)-1-(4-HYDROXYPHENYL)-2-(4-HYDROXY-4-PHENYLPIPERIDINO)-1-PROPANOL(134234-12-1)Related Product Information
- (TETRAHYDRO-2H-PYRAN-4-YL)METHANOL
- 4,4,5,5-TetraMethyl-2-(3-triphenylen-2-yl-phenyl)-[1,3,2]dioxaborolane
- Butyl acetate
- Ethyl acetate
- 1-isopropylpiperidin-4-ol
- 1-phenethylpiperidin-4-ol
- (1S,2S)-(+)-N-METHYLPSEUDOEPHEDRINE
- CHEMBRDG-BB 4003161
- 1-Phenethyl-4-phenyl-4-piperidinol
- 1-[(1S,2S)-2-HYDROXY-1-METHYL-2-(4-TRIISOPROPYLSILANYLOXY-PHENYL)-ETHYL]-4-PHENYL-PIPERIDIN-4-OL
- alpha-[1-(Butylmethylamino)ethyl]-benzyl alcohol
- 4-HYDROXY-1-PIPERIDINEETHANOL 96
- (1S,2S)-1-(4-HYDROXYPHENYL)-2-(4-HYDROXY-4-PHENYLPIPERIDINO)-1-PROPANOL