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TRAMADOL HYDROCHLORIDE

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TRAMADOL HYDROCHLORIDE Basic information

Product Name:
TRAMADOL HYDROCHLORIDE
Synonyms:
  • O-DESMETHYL-CIS-TRAMADOL HCL
  • TRAMODOL HCL
  • AURORA KA-863
  • (+/-)-CIS-2-(DIMETHYLAMINOMETHYL)-1-(3-METHOXYPHENYL)CYCLOHEXANOL HYDROCHLORIDE
  • CIS-TRAMADOL HYDROCHLORIDE
  • trans-(±)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexan-1-ol hydrochloride
  • Cyclohexanol, 2-(dimethylamino)methyl-1-(3-methoxyphenyl)-, hydrochloride, (1R,2R)-rel-
  • Adamon
CAS:
36282-47-0
MF:
C16H26ClNO2
MW:
299.84
EINECS:
252-950-2
Product Categories:
  • Amines, Aromatics, Chiral Reagents, Pharmaceuticals, Intermediates & Fine Chemicals
  • ULTRAM
  • Amines
  • Aromatics
  • Chiral Reagents
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
Mol File:
36282-47-0.mol
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TRAMADOL HYDROCHLORIDE Chemical Properties

Melting point:
178-181 °C
storage temp. 
2-8°C
solubility 
Freely soluble in water and in methanol, very slightly soluble in acetone.
form 
solid
color 
white to off-white
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Safety Information

Hazard Codes 
Xn,N
Risk Statements 
22-51/53
Safety Statements 
61
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
2
HS Code 
2922504500
Toxicity
mouse,LD50,intravenous,61700ug/kg (61.7mg/kg),Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 114, 1978.
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TRAMADOL HYDROCHLORIDE Usage And Synthesis

Description

cis-Tramadol (Item No. 15919) is an analytical reference material categorized as an opioid. cis-Tramadol is regulated as a Schedule IV compound in the United States. This product is intended for research and forensic applications.

Description

cis-Tramadol (hydrochloride) (CRM) (Item No. ISO60149) is a certified reference material categorized as an opioid. cis-Tramadol is regulated as a Schedule IV compound in the United States. cis-Tramadol (hydrochloride) (CRM) (Item No. ISO60149) is provided as a DEA exempt preparation. This product is intended for research and forensic applications.

Chemical Properties

White Solid

Uses

cis-Tramadol is an analgesic that activates the μ-opioid receptor (IC50 = 7.6 μM). It also inhibits serotonin and norepinephrine reuptake and blocks voltage-gated sodium channels. This product is intended for forensic and research applications.[Cayman Chemical]

Uses

An analgesic.

Definition

ChEBI: (R,R)-tramadol hydrochloride is a hydrochloride resulting from the reaction of (R,R)-tramadol with 1 molar equivalent of hydrogen chloride; the (R,R)-enantiomer of the racemic opioid analgesic tramadol hydrochloride, it exhibits ten-fold higher analgesic potency than the (S,S)-enantiomer. It has a role as a delta-opioid receptor agonist, a kappa-opioid receptor agonist, a mu-opioid receptor agonist, an adrenergic uptake inhibitor, an antitussive, a capsaicin receptor antagonist, a muscarinic antagonist, a nicotinic antagonist, a NMDA receptor antagonist, an opioid analgesic, a serotonergic antagonist and a serotonin uptake inhibitor. It contains a (R,R)-tramadol(1+). It is an enantiomer of a (S,S)-tramadol hydrochloride.

TRAMADOL HYDROCHLORIDESupplier

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