TRAMADOL HYDROCHLORIDE
TRAMADOL HYDROCHLORIDE Basic information
- Product Name:
- TRAMADOL HYDROCHLORIDE
- Synonyms:
-
- O-DESMETHYL-CIS-TRAMADOL HCL
- TRAMODOL HCL
- AURORA KA-863
- (+/-)-CIS-2-(DIMETHYLAMINOMETHYL)-1-(3-METHOXYPHENYL)CYCLOHEXANOL HYDROCHLORIDE
- CIS-TRAMADOL HYDROCHLORIDE
- trans-(±)-2-[(dimethylamino)methyl]-1-(3-methoxyphenyl)cyclohexan-1-ol hydrochloride
- Cyclohexanol, 2-(dimethylamino)methyl-1-(3-methoxyphenyl)-, hydrochloride, (1R,2R)-rel-
- Adamon
- CAS:
- 36282-47-0
- MF:
- C16H26ClNO2
- MW:
- 299.84
- EINECS:
- 252-950-2
- Product Categories:
-
- Amines, Aromatics, Chiral Reagents, Pharmaceuticals, Intermediates & Fine Chemicals
- ULTRAM
- Amines
- Aromatics
- Chiral Reagents
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Mol File:
- 36282-47-0.mol
TRAMADOL HYDROCHLORIDE Chemical Properties
- Melting point:
- 178-181 °C
- storage temp.
- 2-8°C
- solubility
- Freely soluble in water and in methanol, very slightly soluble in acetone.
- form
- solid
- color
- white to off-white
- InChI
- 1S/C16H25NO2.ClH/c1-17(2)12-14-7-4-5-10-16(14,18)13-8-6-9-15(11-13)19-3;/h6,8-9,11,14,18H,4-5,7,10,12H2,1-3H3;1H/t14-,16+;/m1./s1
- InChIKey
- PPKXEPBICJTCRU-XMZRARIVSA-N
- SMILES
- Cl.COc1cccc(c1)[C@@]2(O)CCCC[C@@H]2CN(C)C
Safety Information
- Hazard Codes
- Xn,N
- Risk Statements
- 22-51/53
- Safety Statements
- 61
- RIDADR
- UN 2811 6.1/PG 3
- WGK Germany
- 2
- HS Code
- 2922504500
- Storage Class
- 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects - Hazard Classifications
- Acute Tox. 3 Oral
Aquatic Chronic 2
STOT SE 3 - Toxicity
- mouse,LD50,intravenous,61700ug/kg (61.7mg/kg),Arzneimittel-Forschung. Drug Research. Vol. 28, Pg. 114, 1978.
TRAMADOL HYDROCHLORIDE Usage And Synthesis
Description
cis-Tramadol (Item No. 15919) is an analytical reference material categorized as an opioid. cis-Tramadol is regulated as a Schedule IV compound in the United States. This product is intended for research and forensic applications.
Description
cis-Tramadol (hydrochloride) (CRM) (Item No. ISO60149) is a certified reference material categorized as an opioid. cis-Tramadol is regulated as a Schedule IV compound in the United States. cis-Tramadol (hydrochloride) (CRM) (Item No. ISO60149) is provided as a DEA exempt preparation. This product is intended for research and forensic applications.
Chemical Properties
White Solid
Uses
cis-Tramadol is an analgesic that activates the μ-opioid receptor (IC50 = 7.6 μM). It also inhibits serotonin and norepinephrine reuptake and blocks voltage-gated sodium channels. This product is intended for forensic and research applications.[Cayman Chemical]
Uses
An analgesic.
Definition
ChEBI: (R,R)-tramadol hydrochloride is a hydrochloride resulting from the reaction of (R,R)-tramadol with 1 molar equivalent of hydrogen chloride; the (R,R)-enantiomer of the racemic opioid analgesic tramadol hydrochloride, it exhibits ten-fold higher analgesic potency than the (S,S)-enantiomer. It has a role as a delta-opioid receptor agonist, a kappa-opioid receptor agonist, a mu-opioid receptor agonist, an adrenergic uptake inhibitor, an antitussive, a capsaicin receptor antagonist, a muscarinic antagonist, a nicotinic antagonist, a NMDA receptor antagonist, an opioid analgesic, a serotonergic antagonist and a serotonin uptake inhibitor. It contains a (R,R)-tramadol(1+). It is an enantiomer of a (S,S)-tramadol hydrochloride.
References
[1] LIMING SHAO. Derivatives of tramadol for increased duration of effect[J]. Bioorganic & Medicinal Chemistry Letters, 2006, 16 3: Pages 691-694. DOI: 10.1016/j.bmcl.2005.10.024