Nonsteroidal Anti-Inflammatory Drugs (NSAIDS) Antipyretic analgesics Antimigraine Drugs Antigout Drugs Analgesics
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Antipyretic analgesics

Nonsteroidal Anti-Inflammatory Drugs (NSAIDS) Antipyretic analgesics Antimigraine Drugs Antigout Drugs Analgesics
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Antipyretic-analgesics drugs are a class of drugs with antipyretic, analgesic and most also having anti-inflammatory and anti-rheumatic effect. It exerts its antipyretic, analgesic and anti-inflammatory effect primarily by inhibiting the synthesis of prostaglandin in the central nervous system and peripheral tissues. However, for its analgesic effect, it can only be used to clear only weak to moderate pain.

Fever is an intrinsic defense reaction of the body of children with however high temperature fever affecting the body of the children adversely such as causing high-fever seizures with being life-threatening in severe cases. Timely administration of antipyretic-analgesics drugs can reduce the body temperature, alleviate the symptoms and prevent the convulsions and other complications. However, it should be noted that the plummeted temperature and excessive sweating have risks of causing collapse. Therefore, overdose should be avoided. The patients should also drink enough water after taking the drugs. Children of history of febrile convulsions can take it in combination with sedatives such as luminal. In case of fever, early administration of paracetamol tablets can prevent febrile convulsions.

According to the chemical structures, it can be divided into four categories:
1. Aniline; such as phenacetin, acetaminophen and so on.
2. Pyrazolones; such as aminopyrine, dipyrone, phenylbutazone and so on.
3. Salicylic acid; such as aspirin, sodium salicylate.
4. Novel anti-inflammatory analgesics drugs; such as indomethacin, mefenamic acid, ibuprofen and ibuprofen, ketoprofen and so on. This class of drugs has common adverse reactions such as rash, leukopenia, angioedema and anaphylactic shock can occur in small number of patients. Large doses can cause gastrointestinal reactions and liver and kidney dysfunction.

Aspirin has a stimulating effect on the gastrointestinal tract with long-term administration being able to cause gastritis, gastric ulcers and bleeding and inducing bronchial asthma and Reye's syndrome, being manifested as convulsions coma and liver damage. Analgin, in addition to general adverse reactions, occasionally cause severe leukopenia, exfoliative dermatitis and drug fever. Paracetamol class has fewer adverse reactions and is non-irritating to the stomach without causing stomach bleeding except occasional skin rashes and other allergic reactions. However, long-term administration of large doses may have liver and kidney dysfunction. Phenacetin, aminopyrine and other side effects are relative severe, therefore, minimizing the administration of aspirin compound (i.e. APC) class of drugs. Currently there is trend of promoting application of paracetamol and single administration of small amount of water-soluble aspirin.

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Structure:
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C18H15ClN2O2S
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Chemical Name:
PARECOXIB SODIUM
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C19H17N2NaO4S
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C13H10ClN3O4S2
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Pranoprofen
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C15H13NO3
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TETRAHYDROPALMATINE HYDROCHLORIDE
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6024-85-7
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C21H26ClNO4
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Parecoxib
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198470-84-7
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C19H18N2O4S
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Lomerizine
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C27H30F2N2O3
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Antipyrine
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MF:
C11H12N2O
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Chemical Name:
Naproxen
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22204-53-1
MF:
C14H14O3
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Chemical Name:
BUCILLAMINE
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65002-17-7
MF:
C7H13NO3S2
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Chemical Name:
Celecoxib
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169590-42-5
MF:
C17H14F3N3O2S
Structure:
Chemical Name:
Flurbiprofen
CAS:
5104-49-4
MF:
C15H13FO2
Structure:
Chemical Name:
Paeonol
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552-41-0
MF:
C9H10O3
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Chemical Name:
Fentanyl citrate
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990-73-8
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C28H36N2O8
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Rofecoxib
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162011-90-7
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C17H14O4S
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Ketorolac
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74103-06-3
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C15H13NO3
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Chemical Name:
Ibuprofen
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15687-27-1
MF:
C13H18O2
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Chemical Name:
Phenylbutazone
CAS:
50-33-9
MF:
C19H20N2O2
Structure:
Chemical Name:
Neochlorogenic acid
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MF:
C16H18O9
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Chemical Name:
Tetrahydropalmatine
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C21H25NO4
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Allopurinol
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315-30-0
MF:
C5H4N4O
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Chemical Name:
Sodium salicylate
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54-21-7
MF:
C7H5NaO3
Structure:
Chemical Name:
Piroxicam
CAS:
36322-90-4
MF:
C15H13N3O4S
Structure:
Chemical Name:
Eletriptan
CAS:
143322-58-1
MF:
C22H26N2O2S
Structure:
Chemical Name:
Acetaminophen
CAS:
103-90-2
MF:
C8H9NO2
Structure:
Chemical Name:
4-DiMethylaMino Antipyrine
CAS:
58-15-1
MF:
C13H17N3O
Structure:
Chemical Name:
Indometacin
CAS:
53-86-1
MF:
C19H16ClNO4
Structure:
Chemical Name:
Tenoxicam
CAS:
59804-37-4
MF:
C13H11N3O4S2
Structure:
Chemical Name:
D-Glucosamine hydrochloride
CAS:
66-84-2
MF:
C6H14ClNO5
Structure:
Chemical Name:
Meloxicam
CAS:
71125-38-7
MF:
C14H13N3O4S2
Structure:
Chemical Name:
Chlorogenic acid
CAS:
327-97-9
MF:
C16H18O9
Structure:
Chemical Name:
Etodolac
CAS:
41340-25-4
MF:
C17H21NO3
Structure:
Chemical Name:
Ketoprofen
CAS:
22071-15-4
MF:
C16H14O3
Structure:
Chemical Name:
Niflumic acid
CAS:
4394-00-7
MF:
C13H9F3N2O2
Structure:
Chemical Name:
Zolmitriptan
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139264-17-8
MF:
C16H21N3O2
Structure:
Chemical Name:
URICASE
CAS:
9002-12-4
MF:
C18H26N5O14P
Structure:
Chemical Name:
(+)-Bicuculline
CAS:
485-49-4
MF:
C20H17NO6
Structure:
Chemical Name:
Zaltoprofen
CAS:
89482-00-8
MF:
C17H14O3S
Structure:
Chemical Name:
Febuxostat
CAS:
144060-53-7
MF:
C16H16N2O3S
Structure:
Chemical Name:
Salicylamide
CAS:
65-45-2
MF:
C7H7NO2
Structure:
Chemical Name:
Acetylsalicylic acid
CAS:
50-78-2
MF:
C9H8O4
Structure:
Chemical Name:
Dulcitol
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608-66-2
MF:
C6H14O6
Structure:
Chemical Name:
1-(2,6-Dichlorophenyl)-2-indolinone
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15307-86-5
MF:
C14H9Cl2NO
Chemical Name:
florfenicol(Water soluble)
Structure:
Chemical Name:
Mefenamic acid
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61-68-7
MF:
C15H15NO2
Structure:
Chemical Name:
Diclofenac sodium
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15307-79-6
MF:
C14H10Cl2NNaO2
Structure:
Chemical Name:
FENOPROFEN CALCIUM SALT, DIHYDRATE
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71720-56-4
MF:
C15H16O4
Structure:
Chemical Name:
Flufenamic acid
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530-78-9
MF:
C14H10F3NO2
Structure:
Chemical Name:
IBUPROFENPICONOL
CAS:
112017-99-9
MF:
C19H23NO2
Structure:
Chemical Name:
(S)-Flurbiprofen
CAS:
51543-39-6
MF:
C15H13FO2
Structure:
Chemical Name:
Sodium butazolidine
CAS:
129-18-0
MF:
C19H19N2NaO2
Structure:
Chemical Name:
Probenecid
CAS:
57-66-9
MF:
C13H19NO4S
Structure:
Chemical Name:
D-Tetrandrine
CAS:
518-34-3
MF:
C38H42N2O6
Structure:
Chemical Name:
Nimesulide
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51803-78-2
MF:
C13H12N2O5S
Structure:
Chemical Name:
Benzydamine hydrochloride
CAS:
132-69-4
MF:
C19H23N3O.ClH
Structure:
Chemical Name:
Aceclofenac
CAS:
89796-99-6
MF:
C16H13Cl2NO4
Structure:
Chemical Name:
Carprofen
CAS:
53716-49-7
MF:
C15H12ClNO2
Structure:
Chemical Name:
Droxicam
CAS:
90101-16-9
MF:
C16H11N3O5S
Structure:
Chemical Name:
Lobenzarit
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63329-53-3
MF:
C14H10ClNO4
Structure:
Chemical Name:
Sasapyrine
CAS:
552-94-3
MF:
C14H10O5
Structure:
Chemical Name:
Oxaprozin
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21256-18-8
MF:
C18H15NO3
Structure:
Chemical Name:
Leflunomide
CAS:
75706-12-6
MF:
C12H9F3N2O2
Structure:
Chemical Name:
Tiropramide Hydrochloride
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53567-47-8
MF:
C28H42ClN3O3
Structure:
Chemical Name:
N-Sulfo-glucosamine potassium salt
CAS:
31284-96-5
MF:
C6H12KNO8S
Structure:
Chemical Name:
Fenbufen
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36330-85-5
MF:
C16H14O3
Structure:
Chemical Name:
Nabumetone
CAS:
42924-53-8
MF:
C15H16O2
Structure:
Chemical Name:
Carbasalate calcium
CAS:
5749-67-7
MF:
C18H14CaO8.CH4N2O
Structure:
Chemical Name:
Methocarbamol
CAS:
532-03-6
MF:
C11H15NO5
Structure:
Chemical Name:
Sulindac
CAS:
38194-50-2
MF:
C20H17FO3S
Structure:
Chemical Name:
Diclofenac diethylamine
CAS:
78213-16-8
MF:
C18H22Cl2N2O2
Structure:
Chemical Name:
Sumatriptan
CAS:
103628-46-2
MF:
C14H21N3O2S
Structure:
Chemical Name:
ROTUNDINUM
CAS:
2934-97-6
MF:
C21H25NO4
Structure:
Chemical Name:
2-Hydroxybenzylamine
CAS:
932-30-9
MF:
C7H9NO
Structure:
Chemical Name:
Meptazinol hydrochloride
CAS:
59263-76-2
MF:
C15H24ClNO
Structure:
Chemical Name:
Dexketoprofen trometamol
CAS:
156604-79-4
MF:
C16H14O3.C4H11NO3
Structure:
Chemical Name:
L-Arginine acetylsalicylate
CAS:
37466-21-0
MF:
C15H22N4O6
Structure:
Chemical Name:
Loxoprofen sodium
CAS:
80382-23-6
MF:
C15H17NaO3
Structure:
Chemical Name:
Propyphenazone
CAS:
479-92-5
MF:
C14H18N2O
Structure:
Chemical Name:
Nefopam hydrochloride
CAS:
23327-57-3
MF:
C17H20ClNO
Structure:
Chemical Name:
DL-Lysine acetylsalicylate
CAS:
62952-06-1
MF:
C15H22N2O6
Structure:
Chemical Name:
Flunixin meglumine
CAS:
42461-84-7
MF:
C21H28F3N3O7
Structure:
Chemical Name:
2-Ethoxybenzamide
CAS:
938-73-8
MF:
C9H11NO2
Structure:
Chemical Name:
OXYPHENBUTAZONE HYDRATE
CAS:
7081-38-1
MF:
C19H22N2O4
Structure:
Chemical Name:
Clofenamic acid
CAS:
13278-36-9
MF:
C13H10ClNO2
Structure:
Chemical Name:
Propacetamol hydrochloride
CAS:
66532-86-3
MF:
C14H21ClN2O3
Structure:
Chemical Name:
Butibufen
CAS:
55837-18-8
MF:
C14H20O2
Structure:
Chemical Name:
MECLOFENAMATE SODIUM
CAS:
6385-02-0
MF:
C14H10Cl2NO2.Na
Structure:
Chemical Name:
Dipyrone
CAS:
68-89-3
MF:
C13H16N3NaO4S
Structure:
Chemical Name:
Naproxen sodium
CAS:
26159-34-2
MF:
C14H13O3.Na
Structure:
Chemical Name:
(R)-2-Flurbiprofen
CAS:
51543-40-9
MF:
C15H13FO2
Structure:
Chemical Name:
Loxoprofen
CAS:
68767-14-6
MF:
C15H18O3
Structure:
Chemical Name:
CHELIDONINE
CAS:
476-32-4
MF:
C20H19NO5
Structure:
Chemical Name:
CINCHOPHEN
CAS:
132-60-5
MF:
C16H11NO2
Structure:
Chemical Name:
FLURBIPROFEN AXETIL
CAS:
91503-79-6
MF:
C19H19FO4
Structure:
Chemical Name:
1-PHENYLSEMICARBAZIDE
CAS:
103-03-7
MF:
C7H9N3O
Structure:
Chemical Name:
Florfenicol
CAS:
73231-34-2
MF:
C12H14Cl2FNO4S
Structure:
Chemical Name:
Bulleyaconitine A
CAS:
107668-79-1
MF:
C35H49NO9
Structure:
Chemical Name:
Diclofenac potassium
CAS:
15307-81-0
MF:
C14H10Cl2KNO2
Structure:
Chemical Name:
Diflunisal
CAS:
22494-42-4
MF:
C13H8F2O3