Basic information Description References Safety Supplier Related
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Lornoxicam

Basic information Description References Safety Supplier Related

Lornoxicam Basic information

Product Name:
Lornoxicam
Synonyms:
  • LORNOXICAM
  • AKOS 93662
  • 6-Chloro-4-hydroxy-2-methyl-N-(2-pyridyl)-2H-thieno[2,3-e][1,2]thiazine-3-carboxamide 1,1-dioxide
  • LornoxicaM for injection
  • 6-Chloro-4-hydroxy-2-Methyl-N-2-pyridinyl-
  • LornoxicaM API
  • 6-Chloro-4-hydroxy-2-Methyl-N-pyridin-2-yl-2H-thieno[2,3-e][1,2]thiazine-3-carboxaMide
  • LornoxicaM (Xefo)
CAS:
70374-39-9
MF:
C13H10ClN3O4S2
MW:
371.82
EINECS:
630-354-7
Product Categories:
  • AVITA
  • Other APIs
  • APIs
  • Inhibitors
  • Fused Ring Systems
  • API
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Sulfur & Selenium Compounds
Mol File:
70374-39-9.mol
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Lornoxicam Chemical Properties

Melting point:
225-230°C (dec.)
Density 
1.742±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility 
DMSO: >5mg/mL (warmed)
pka
pKa2 4.7(at 25℃)
form 
powder
color 
faint yellow to dark yellow
Merck 
14,5582
InChIKey
WLHQHAUOOXYABV-UHFFFAOYSA-N
CAS DataBase Reference
70374-39-9(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xi,T+
Risk Statements 
36/37/38-28
Safety Statements 
26-36-45-36/37-28
RIDADR 
UN 2811 6.1 / PGII
WGK Germany 
3
RTECS 
XJ9095000
HazardClass 
IRRITANT
PackingGroup 
II
HS Code 
29349990
Toxicity
LD50 orally in mice, rats, rabbits, dogs, monkeys: >10 mg/kg (Pruss)
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Lornoxicam Usage And Synthesis

Description

Lornoxicam (Trade name: “Xefo”) belongs to a non-steroidal anti-inflammatory drug. As a kind of oxicam class drug, it has analgesic, anti-inflammatory and antipyretic properties. It can be used for the treatment of various type of acute mild to moderate pain which results from inflammatory diseases of the joints, osteoarthritis, surgery, sciatica and rheumatic diseases. Lornoxicam is capable of potently inhibiting the prostaglandin biosynthesis process, making it have highly pronounced efficacy. The exact mechanism of Lornoxicam is not exactly understood. However, it is indicated that Lornoxicam can inhibit the prostaglandin and thromboxane synthesis by inhibiting both COX-1 and COX-2, leading to reduction of inflammation, pain, fever, and swelling.

References

https://www.drugbank.ca/drugs/DB06725
https://en.wikipedia.org/wiki/Lornoxicam

Description

Lornoxicam is a nonselective NSAID for oral and intravenous administration. It has been available for human use since two decades and there is a growing body of evidence supporting its efficacy and tolerability for management of acute pain.
Xefo, a member of the oxicam family of nonsteroidal antiinflammatory agents, was launched in Denmark for mild to moderate pain and inflammation. A seven step synthesis, beginning with 2,5-dichlorothiophene, provides access to this compound. It inhibits prostaglandin synthesis at the level of cyclooxygenase (Cox1 :Cox2 = 0.6) but does not inhibit 5-lipoxygenase. Xefo did not increase serum levels of pepsinogen I (an indicator of gastric mucosal status) and readily penetrates perivascular interstitial spaces including synovial fluid. It is as effective as morphine, meperidine and tramadol in relieving post operative pain and as efficient as other NSAlDs in relieving the symptoms of osteoarthritis and rheumatoid arthritis. It is 100 times more potent than Tenoxicam in inhibiting PGD2 and more active than indomethacin (6x) or piroxicam (10x) in preventing arachadonic acid influenced lethality in mice. Xefo has inhibitor effects on spinal nocicceptive processing presumably via release of endogenous opiods and evidence suggests it is good for migraine.

Chemical Properties

Crystalline Solid

Originator

Nycomed Amersham (Norway)

Uses

keratolytic, antiacne, antineoplastic

Uses

Lornoxicam belongs to the oxicam class. It has anti-inflammatory and antipyretic properties. Lornoxicam prevents the synthesis of prostaglandin (PG) by inhibiting cyclo-oxygenase. It is used to relieve various types of symptoms associated with osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute sciatica and low back pain.Lornoxicam is approved for use in Japan.
Lornoxicam has been used as a drug in melanin binding study with cassette dosing and rapid equilibrium dialysis inserts. Lornoxicam differs from other oxicam compounds in its potent inhibition of prostaglandin biosynthesis, a property that explains the particularly pronounced efficacy of the drug.

Uses

For the treatment of acute mild to moderate pain, as well as pain and inflammation of the joints caused by certain types of rheumatic diseases.

Uses

Cyclooxygenase inhibitor; structurally similar to tenoxicam. Anti-inflammatory; analgesic

Definition

ChEBI: A thienothiazine-derived monocarboxylic acid amide obtained by formal condensation of the carboxy group of 6-chloro-4-hydroxy-2-methylthieno[2,3-e][1,2]thiazine-3-carboxylic acid 1,1-dioxide with the amino group of 2-aminopyridine. Used for th treatment of pain, primarily resulting from inflammatory diseases of the joints, osteoarthritis, surgery, sciatica and other inflammations.

Indications

Lornoxicam is a non-steroidal anti-inflammatory drug (NSAID) that is used as a painkiller (analgesic). A high level of pain relief is experienced by about 45% of those with moderate to severe postoperative dental pain after a single dose of lornoxicam 8 mg, compared to about 10% with placebo. This is comparable to the proportion experiencing the same level of pain relief with ibuprofen 200 to 400 mg. Adverse events were generally mild and did not differ from placebo in these singe dose studies. There were insufficient data to assess duration of action, but it is likely to be similar to ibuprofen 200 mg.

brand name

Xefo

LornoxicamSupplier

Chongqing Landtower Pharmaceutical Co., Ltd. Gold
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