URICASE Chemical Properties

storage temp. 

-20°C

form 

lyophilized powder

color 

White to off-white

biological source

Bacillus sp. (B. fastidiosus)

Water Solubility 

Hardly soluble in water, slightly soluble in buffer alkaline solution.

Merck 

13,9944

Specific Activity

15-30units/mg protein (biuret)

EPA Substance Registry System

Oxidase, urate (9002-12-4)

Safety Information

Safety Statements 

24/25

WGK Germany 

3

RTECS 

YU7100000

F 

10-21

TSCA 

Yes

HS Code 

35079090

MSDS

• Language:English Provider:SigmaAldrich

URICASE Usage And Synthesis

Chemical Properties

White powder

Uses

Uricase is very important for the determination of uric acid in biological fluids. Uricase is an important medical enzyme which can be used to determine urate in clinical analysis. The enzyme Urate oxidase (UO) catalyzes the oxidation of uric acid to 5-hydroxyisourate.

Uses

Uricase from Arthrobacter globiformis has been used for coating the electrodes in - biosensor fabrication for the detection of uric acid in urine samples. It has also been used for analysing the effect of Zn, Cu, Mg, and Mn ions on uricase.

Uses

In the determination of serum and urine uric acid.

General Description

Mice deficient in uricase develop uric acid nephropathy and diabetes insipidus which can be mitigated with recombinant uricase treatment.

Biochem/physiol Actions

Uricase catalyzes the oxidation of uric acid to 5-hydroxyisourate, which subsequently forms (S)-allantoin. It is involved in purine metabolism, urate degradation and (S)-allantoin formation .

URICASE(9002-12-4)Related Product Information

• PHENYLSELENOL
• COBALT(II) ACETYLACETONATE
• Ethyl isocyanoacetate
• Cupric acetylacetonate
• Tosylmethyl isocyanide
• Aluminum acetylacetonate
• 1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE
• METHYL ISOCYANOACETATE
• 2,4-PENTANEDIONE, SILVER DERIVATIVE
• DICHLORO(ETHYLENEDIAMINE)PLATINUM(II)
• N-BUTYLISOCYANIDE
• Benzyl isocyanide
• Tris(2,4-pentanedionato)chroMiuM(III)
• SALCOMINE
• TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III)
• TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III)
• Ferric acetylacetonate
• Uric acid