Benzyl isocyanide Chemical Properties

Boiling point:

105-106 °C75 mm Hg(lit.)

Density 

0.962 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.521(lit.)

Flash point:

175 °F

storage temp. 

-20°C

pka

27.4

form 

clear liquid

color 

Colorless to Red to Green

Safety Information

Hazard Codes 

Xn

Risk Statements 

20/21/22

Safety Statements 

36/37

RIDADR 

UN 3334

WGK Germany 

3

HS Code 

29269090

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich

Benzyl isocyanide Usage And Synthesis

Chemical Properties

clear colorless to yellowish liquid

Uses

Benzyl Isocyanide is used in the preparation of arylamide compounds. also used as a catalyst in the cycloaddition of norbornenes with internal and terminal acetylenes.

Application

Benzyl isocyanide forms phosphaalkene-containing complexes. Benzyl isocyanide was used in the synthesis of Ru(II) complexes containing hydrazine and benzyl isocyanide ligands. It was used in a three-component coupling process leading to O- and N-arylamides.

Synthesis

Synthesis of benzyl isocyanide
In a 500-mL, round-bottomed flask equipped with a magnetic stirring bar and a pressure-equalizing funnel are placed 5-benzylaminotetrazole (10.5 g, 60 mmol), 100 mL of 10% sodium hydroxide solution, and 70 mL of dichloromethane. The mixture is cooled to 0°C and a solution of NaOBr in water (165 mL, 65 mmol) (Note 2) is added with vigorous stirring over a 15-min period (Note 3). The dichloromethane layer is separated and the aqueous phase extracted with five 50-mL portions of dichloromethane. The combined dichloromethane extracts are dried over anhydrous MgSO4, the drying agent is removed by filtration, and the dichloromethane is removed by simple distillation. The pressure is then reduced to ~20 mm with an aspirator and benzyl isocyanide is distilled at 98–100°C; yield: 5.91 g (84%) (Note 4) and (Note 5).
Organic Syntheses, Coll. Vol. 7, p. 27, 1990
http://www.orgsyn.org

Benzyl isocyanide(10340-91-7)Related Product Information

• ISOCYANIC ACID
• CYCLOHEXYL ISOCYANIDE
• Benzeneacetonitrile
• Benzyl chloride
• Benzyl isocyanate
• Ethyl acetoacetate
• 3-(ISOCYANOMETHYL)BENZYL-ISOCYANIDE
• 4-(ISOCYANOMETHYL)BENZYL-ISOCYANIDE