CYCLOHEXYL ISOCYANIDE Chemical Properties

Melting point:

6.45°C

Boiling point:

173-176 °C

Density 

0.878 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.45(lit.)

Flash point:

170 °F

storage temp. 

Store at +2°C to +8°C.

form 

Liquid

color 

Clear colorless to slightly brown

BRN 

3662332

Stability:

Stable. Incompatible with strong acids, strong bases, strong reducing agents, strong oxidizing agents. Flammable.

CAS DataBase Reference

931-53-3(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn,T

Risk Statements 

20/21/22-23/24/25

Safety Statements 

36/37-45-24/25

RIDADR 

UN 2810 6.1/PG 2

WGK Germany 

3

F 

10-13-21

HazardClass 

6.1

PackingGroup 

III

HS Code 

29299090

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

CYCLOHEXYL ISOCYANIDE Usage And Synthesis

Chemical Properties

colourless liquid

Uses

Cyclohexyl Isocyanide can be used as novel arginase inhibitors to treat diseases.

Definition

ChEBI: Cyclohexyl isocyanide is an isocyanide having a cyclohexyl group attached to nitrogen. It is a conjugate base of a cyclohexyl isocyanide(1+).

Preparation

CAUTION: Use a well-ventilated hood and take all precautions before using phosgene.
To a flask equipped as in Preparation 3-1 is added 1.27 kg (10.0 moles) of N-cyclohexylformamide, 3.20 liters of triethylamine, and 4.50 liters of methylene chloride. The solution is stirred while phosgene is rapidly added (300-400 gm/hr) to cause vigorous refluxing. Refluxing ceases after 1.04 kg (10.2 moles) of phosgene have been added and the addition is stopped. The reaction mixture is cooled to 22-25°C, 400 gm (23.5 moles) of ammonia gas added over a period of 1-2 hr, the mixture filtered then concentrated under reduced pressure, and the residue distilled to afford 955 gm (88%), b.p. 67-72°C (14 mm Hg).

General Description

Cyclohexyl isocyanide reacts with dimethyl acetylenedicarboxylate to give a mixture of cyclopenta[b]pyridine derivatives, azaspirononatriene derivative and the azabicyclononatriene. It reacts with dialkyl acetylenedicarboxylates to form 1:1 intermediate which on facile addition to 1-benzylisatin and tryptantrin yields highly functionalized novel unsaturated γ-spiroiminolactones.

CYCLOHEXYL ISOCYANIDE(931-53-3)Related Product Information

• 3,4-Diaminobenzoic acid
• Dimedone
• Benzyl isocyanide
• Benzeneacetonitrile
• Benzyl chloride
• Benzyl isocyanate
• CYCLOHEXYL ISOCYANIDE
• 1-ADAMANTANEISOCYANIDE
• 4-(N-T-BUTOXYCARBONYLAMINO)CYCLOHEXYLISOCYANIDE
• 2-(1'-ISOCYANOCYCLOHEXYL) ACETIC ACID METHYL ESTER
• ETHYL 1-ISOCYANOCYCLOHEXANECARBOXYLATE
• TRANS-ETHYL-2-ISOCYANO-CYCLOHEXYLCARBOXYLATE
• (S,S)-1,2-DIISOCYANOCYCLO-HEXANE
• 1,2-DIISOCYANOCYCLOHEXANE
• Cyclohexanecarboxylic acid, 1-isocyano-, methyl ester (9CI)
• CIS-ETHYL-2-ISOCYANOCYCLO-HEXYLCARBOXYLATE
• BIO-FARMA BF001930
• Cyclohexane, 1,4-diisocyano- (9CI)