CYCLOHEXYL ISOCYANIDE
CYCLOHEXYL ISOCYANIDE Basic information
- Product Name:
- CYCLOHEXYL ISOCYANIDE
- Synonyms:
-
- Cyclohexane, isocyano-
- Cyclohexaneisonitrile
- BIO-FARMA BF001328
- ISOCYANOCYCLOHEXANE
- HANSA ISN-0519
- CYCLOHEXYL ISOCYANIDE
- CYCLOHEXYL ISONITRILE
- Cyclohexyl #niso-cyanide
- CAS:
- 931-53-3
- MF:
- C7H11N
- MW:
- 109.17
- EINECS:
- 213-238-7
- Product Categories:
-
- ISONITRITE
- Mol File:
- 931-53-3.mol
CYCLOHEXYL ISOCYANIDE Chemical Properties
- Melting point:
- 6.45°C
- Boiling point:
- 173-176 °C
- Density
- 0.878 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.45(lit.)
- Flash point:
- 170 °F
- storage temp.
- Store at +2°C to +8°C.
- form
- Liquid
- color
- Clear colorless to slightly brown
- BRN
- 3662332
- Stability:
- Stable. Incompatible with strong acids, strong bases, strong reducing agents, strong oxidizing agents. Flammable.
- CAS DataBase Reference
- 931-53-3(CAS DataBase Reference)
Safety Information
- Hazard Codes
- Xn,T
- Risk Statements
- 20/21/22-23/24/25
- Safety Statements
- 36/37-45-24/25
- RIDADR
- UN 2810 6.1/PG 2
- WGK Germany
- 3
- F
- 10-13-21
- HazardClass
- 6.1
- PackingGroup
- III
- HS Code
- 29299090
MSDS
- Language:English Provider:SigmaAldrich
- Language:English Provider:ACROS
CYCLOHEXYL ISOCYANIDE Usage And Synthesis
Chemical Properties
colourless liquid
Uses
Cyclohexyl Isocyanide can be used as novel arginase inhibitors to treat diseases.
Definition
ChEBI: Cyclohexyl isocyanide is an isocyanide having a cyclohexyl group attached to nitrogen. It is a conjugate base of a cyclohexyl isocyanide(1+).
Preparation
CAUTION: Use a well-ventilated hood and take all precautions before using phosgene.
To a flask equipped as in Preparation 3-1 is added 1.27 kg (10.0 moles) of N-cyclohexylformamide, 3.20 liters of triethylamine, and 4.50 liters of methylene chloride. The solution is stirred while phosgene is rapidly added (300-400 gm/hr) to cause vigorous refluxing. Refluxing ceases after 1.04 kg (10.2 moles) of phosgene have been added and the addition is stopped. The reaction mixture is cooled to 22-25°C, 400 gm (23.5 moles) of ammonia gas added over a period of 1-2 hr, the mixture filtered then concentrated under reduced pressure, and the residue distilled to afford 955 gm (88%), b.p. 67-72°C (14 mm Hg).
General Description
Cyclohexyl isocyanide reacts with dimethyl acetylenedicarboxylate to give a mixture of cyclopenta[b]pyridine derivatives, azaspirononatriene derivative and the azabicyclononatriene. It reacts with dialkyl acetylenedicarboxylates to form 1:1 intermediate which on facile addition to 1-benzylisatin and tryptantrin yields highly functionalized novel unsaturated γ-spiroiminolactones.
References
[1] Khalili, Gholamhossein. “ChemInform Abstract: A Diastereoselective Synthesis of (Z)-3-[(Aryl)(hydroxyimino)methyl] -2-cyclohexyl-1-(cyclohexylamino)imidazo[5,1-a]isoquinolinium Chlorides from Isoquinoline, Chlorooximes, and Cyclohexyl Isocyanide.” ChemInform 47 25 (2016).
[2] M. Anary‐Abbasinejad, M. Heidari, N. Shams. “One-pot synthesis of highly functionalised 1H-pyrazoles from arylcarbohydrazides, cyclohexyl isocyanide, and acetylene diesters.” Arkivoc 2012 1 (2012).
[3] Anary‐Abbasinejad, M. M. Jaafari and Mahdiyeh Talebizadeh. “One-pot Four-component Reaction between Arylamines, Arylglyoxals, Cyclohexyl Isocyanide, and Acetylene Diesters: An Efficient Synthesis of 2H-iminopyran Derivatives.” 2019. 0.
[4] Alireza Hassanabadi. “ChemInform Abstract: Use of Cyclohexyl Isocyanide in the Esterification of N-Benzoyl α-Amino Acid Derivatives.” ChemInform 43 3 (2011).
[5] A. Hassanabadi. “The use of cyclohexyl isocyanide in the esterification of N -benzoyl α-amino acids derivatives.” Journal of Chemical Research-s 18 1 (2011): 468–470.
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CYCLOHEXYL ISOCYANIDE(931-53-3)Related Product Information
- 3,4-Diaminobenzoic acid
- Dimedone
- Benzyl isocyanide
- Benzeneacetonitrile
- Benzyl chloride
- Benzyl isocyanate
- CYCLOHEXYL ISOCYANIDE
- 1-ADAMANTANEISOCYANIDE
- 4-(N-T-BUTOXYCARBONYLAMINO)CYCLOHEXYLISOCYANIDE
- 2-(1'-ISOCYANOCYCLOHEXYL) ACETIC ACID METHYL ESTER
- ETHYL 1-ISOCYANOCYCLOHEXANECARBOXYLATE
- TRANS-ETHYL-2-ISOCYANO-CYCLOHEXYLCARBOXYLATE
- (S,S)-1,2-DIISOCYANOCYCLO-HEXANE
- 1,2-DIISOCYANOCYCLOHEXANE
- Cyclohexanecarboxylic acid, 1-isocyano-, methyl ester (9CI)
- CIS-ETHYL-2-ISOCYANOCYCLO-HEXYLCARBOXYLATE
- BIO-FARMA BF001930
- Cyclohexane, 1,4-diisocyano- (9CI)