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METHYL ISOCYANOACETATE

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METHYL ISOCYANOACETATE Basic information

Product Name:
METHYL ISOCYANOACETATE
Synonyms:
  • Methyl isocyanoacetate, technical grade
  • Methyl isocyanoacetate, 95%, tech.
  • (2-Oxo-2-methoxyethyl) isocyanide
  • 2-Isocyanoacetic acid methyl ester
  • 2-Oxo-2-methoxyethyl isocyanide
  • Methyl 2-isocyanoacetate
  • Methyl isocyanoacetate, tech., 95% 5GR
  • Acetic acid, 2-isocyano-, Methyl ester
CAS:
39687-95-1
MF:
C4H5NO2
MW:
99.09
EINECS:
254-593-8
Product Categories:
  • straight chain compounds
  • Naphthyridine,Quinoline
  • Isocyanides
  • Nitrogen Compounds
  • Organic Building Blocks
  • Building Blocks
  • pharmacetical
  • Chemical Synthesis
  • Nitrogen Compounds
  • Organic Building Blocks
Mol File:
39687-95-1.mol
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METHYL ISOCYANOACETATE Chemical Properties

Boiling point:
75-76 °C10 mm Hg(lit.)
Density 
1.09 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.417(lit.)
Flash point:
193 °F
storage temp. 
2-8°C
solubility 
Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
form 
Liquid
color 
Clear yellow to brown
Water Solubility 
Miscible with organic solvents. Slightly miscible with water.
BRN 
3537963
CAS DataBase Reference
39687-95-1(CAS DataBase Reference)
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Safety Information

Hazard Codes 
C
Risk Statements 
20/21/22-34
Safety Statements 
26-36/37/39-45
RIDADR 
UN 2922 8/PG 2
WGK Germany 
3
8-9-32-13-19
HazardClass 
8
PackingGroup 
II
HS Code 
29291090

MSDS

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METHYL ISOCYANOACETATE Usage And Synthesis

Chemical Properties

CLEAR YELLOW TO BROWN LIQUID

Uses

Methyl isocyanoacetate is used in the copper-catalyzed, diastereoselective synthesis of oxazolines. It is involved in the direct aldol reaction with carbonyl compounds to prepare corresponding oxazoline by using catechol-copper network catalyst. Further, it is also involved in four-component Ugi condensation reaction. It undergoes asymmetric aldol reaction with fluorinated benzaldehyde using gold(I) as a catalyst.

Uses

Methyl isocyanoacetate has been used in the copper-catalyzed, diastereoselective synthesis of oxazolines.

General Description

Methyl isocyanoacetate undergoes direct aldol reaction with carbonyl compounds in the presence of solid-phase catechol-copper network catalyst to yield corresponding oxazolines. It also participates in four-component Ugi condensation reaction.

METHYL ISOCYANOACETATE Preparation Products And Raw materials

Preparation Products

METHYL ISOCYANOACETATESupplier

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