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METHYL ISOCYANOACETATE

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METHYL ISOCYANOACETATE Basic information

Product Name:
METHYL ISOCYANOACETATE
Synonyms:
  • Methyl isocyanoacetate, technical grade
  • Methyl isocyanoacetate, 95%, tech.
  • (2-Oxo-2-methoxyethyl) isocyanide
  • 2-Isocyanoacetic acid methyl ester
  • 2-Oxo-2-methoxyethyl isocyanide
  • Methyl 2-isocyanoacetate
  • Methyl isocyanoacetate, tech., 95% 5GR
  • Acetic acid, 2-isocyano-, Methyl ester
CAS:
39687-95-1
MF:
C4H5NO2
MW:
99.09
EINECS:
254-593-8
Product Categories:
  • straight chain compounds
  • Naphthyridine,Quinoline
  • Isocyanides
  • Nitrogen Compounds
  • Organic Building Blocks
  • Building Blocks
  • pharmacetical
  • Chemical Synthesis
  • Nitrogen Compounds
  • Organic Building Blocks
Mol File:
39687-95-1.mol
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METHYL ISOCYANOACETATE Chemical Properties

Boiling point:
75-76 °C10 mm Hg(lit.)
Density 
1.09 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.417(lit.)
Flash point:
193 °F
storage temp. 
2-8°C
form 
Liquid
color 
Clear yellow to brown
Water Solubility 
Miscible with organic solvents. Slightly miscible with water.
BRN 
3537963
CAS DataBase Reference
39687-95-1(CAS DataBase Reference)
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Safety Information

Hazard Codes 
C
Risk Statements 
20/21/22-34
Safety Statements 
26-36/37/39-45
RIDADR 
UN 2922 8/PG 2
WGK Germany 
3
8-9-32-13-19
HazardClass 
8
PackingGroup 
II
HS Code 
29291090

MSDS

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METHYL ISOCYANOACETATE Usage And Synthesis

Chemical Properties

CLEAR YELLOW TO BROWN LIQUID

Uses

Methyl isocyanoacetate is used in the copper-catalyzed, diastereoselective synthesis of oxazolines. It is involved in the direct aldol reaction with carbonyl compounds to prepare corresponding oxazoline by using catechol-copper network catalyst. Further, it is also involved in four-component Ugi condensation reaction. It undergoes asymmetric aldol reaction with fluorinated benzaldehyde using gold(I) as a catalyst.

Uses

Methyl isocyanoacetate has been used in the copper-catalyzed, diastereoselective synthesis of oxazolines.

General Description

Methyl isocyanoacetate undergoes direct aldol reaction with carbonyl compounds in the presence of solid-phase catechol-copper network catalyst to yield corresponding oxazolines. It also participates in four-component Ugi condensation reaction.

METHYL ISOCYANOACETATE Preparation Products And Raw materials

Preparation Products

METHYL ISOCYANOACETATESupplier

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