METHYL ISOCYANOACETATE Chemical Properties

Boiling point:

75-76 °C10 mm Hg(lit.)

Density 

1.09 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.417(lit.)

Flash point:

193 °F

storage temp. 

2-8°C

form 

Liquid

color 

Clear yellow to brown

Water Solubility 

Miscible with organic solvents. Slightly miscible with water.

BRN 

3537963

CAS DataBase Reference

39687-95-1(CAS DataBase Reference)

Safety Information

Hazard Codes 

C

Risk Statements 

20/21/22-34

Safety Statements 

26-36/37/39-45

RIDADR 

UN 2922 8/PG 2

WGK Germany 

3

F 

8-9-32-13-19

HazardClass 

8

PackingGroup 

II

HS Code 

29291090

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

METHYL ISOCYANOACETATE Usage And Synthesis

Chemical Properties

CLEAR YELLOW TO BROWN LIQUID

Uses

Methyl isocyanoacetate is used in the copper-catalyzed, diastereoselective synthesis of oxazolines. It is involved in the direct aldol reaction with carbonyl compounds to prepare corresponding oxazoline by using catechol-copper network catalyst. Further, it is also involved in four-component Ugi condensation reaction. It undergoes asymmetric aldol reaction with fluorinated benzaldehyde using gold(I) as a catalyst.

Uses

Methyl isocyanoacetate has been used in the copper-catalyzed, diastereoselective synthesis of oxazolines.

General Description

Methyl isocyanoacetate undergoes direct aldol reaction with carbonyl compounds in the presence of solid-phase catechol-copper network catalyst to yield corresponding oxazolines. It also participates in four-component Ugi condensation reaction.

METHYL ISOCYANOACETATE(39687-95-1)Related Product Information

• ISONICOTINOYL CHLORIDE HYDROCHLORIDE
• 2-IsocyanatoethylAcrylate
• ISOPROPYLHYDRAZINE HYDROCHLORIDE
• Isopropylsulfonamide
• 2,3,5,6-tetrafluoro-4-methoxymethylbenzyl-1R, trans-(Z)-3-(3,3,3-trifluoro-1-propenyl)-2,2-dimethylcyclopropane carboxylate
• HYDROGEN IONOPHORE IV
• alpha-Cypermethrin
• Isobutaneboronic acid
• Methyl isobutyrate
• Ethyl isobutyrylacetate
• Isopropenylboronic acid pinacol ester
• ETHYL 4-METHYLVALERATE
• URANIUM
• Potassium cyanate
• Ethyl isocyanoacetate
• 2-BROMOPHENYL ISOCYANATE
• Benzyl isocyanate
• 1,3,5-Tri-2-propenyl-1,3,5-triazine-2,4,6(1H,3H,5H)-trione