METHYL ISOCYANOACETATE Chemical Properties

Boiling point:

75-76 °C10 mm Hg(lit.)

Density 

1.09 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.417(lit.)

Flash point:

193 °F

storage temp. 

2-8°C

solubility 

Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)

form 

Liquid

color 

Clear yellow to brown

Water Solubility 

Miscible with organic solvents. Slightly miscible with water.

BRN 

3537963

CAS DataBase Reference

39687-95-1(CAS DataBase Reference)

Safety Information

Hazard Codes 

C

Risk Statements 

20/21/22-34

Safety Statements 

26-36/37/39-45

RIDADR 

UN 2922 8/PG 2

WGK Germany 

3

F 

8-9-32-13-19

HazardClass 

8

PackingGroup 

II

HS Code 

29291090

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

METHYL ISOCYANOACETATE Usage And Synthesis

Chemical Properties

CLEAR YELLOW TO BROWN LIQUID

Uses

Methyl isocyanoacetate is used in the copper-catalyzed, diastereoselective synthesis of oxazolines. It is involved in the direct aldol reaction with carbonyl compounds to prepare corresponding oxazoline by using catechol-copper network catalyst. Further, it is also involved in four-component Ugi condensation reaction. It undergoes asymmetric aldol reaction with fluorinated benzaldehyde using gold(I) as a catalyst.

Uses

Methyl isocyanoacetate has been used in the copper-catalyzed, diastereoselective synthesis of oxazolines.

General Description

Methyl isocyanoacetate undergoes direct aldol reaction with carbonyl compounds in the presence of solid-phase catechol-copper network catalyst to yield corresponding oxazolines. It also participates in four-component Ugi condensation reaction.

METHYL ISOCYANOACETATE(39687-95-1)Related Product Information

• ISONICOTINOYL CHLORIDE HYDROCHLORIDE
• 2-Isocyanatoethyl Acrylate
• ISOPROPYLHYDRAZINE HYDROCHLORIDE
• Isopropylsulfonamide
• 2,3,5,6-tetrafluoro-4-methoxymethylbenzyl-1R, trans-(Z)-3-(3,3,3-trifluoro-1-propenyl)-2,2-dimethylcyclopropane carboxylate
• HYDROGEN IONOPHORE IV
• alpha-Cypermethrin
• Isobutaneboronic acid
• Methyl isobutyrate
• Ethyl isobutyrylacetate
• Isopropenylboronic acid pinacol ester
• ETHYL 4-METHYLVALERATE
• URANIUM
• Potassium cyanate
• Ethyl isocyanoacetate
• 2-BROMOPHENYL ISOCYANATE
• Benzyl isocyanate
• 1,3,5-Tri-2-propenyl-1,3,5-triazine-2,4,6(1H,3H,5H)-trione