Isobutaneboronic acid Chemical Properties

Melting point:

108-111 °C(lit.)

Boiling point:

180.0±23.0 °C(Predicted)

Density 

0.910±0.06 g/cm3(Predicted)

storage temp. 

Inert atmosphere,Store in freezer, under -20°C

solubility 

Acetonitrile (Slightly), DMSO, Methanol (Slightly)

pka

10.49±0.43(Predicted)

form 

Crystalline Powder or Flakes

color 

White to cream

CAS DataBase Reference

84110-40-7(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

37/39-26

WGK Germany 

3

TSCA 

No

HazardClass 

IRRITANT

HS Code 

29319090

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

Isobutaneboronic acid Usage And Synthesis

Description

Isobutaneboronic acid is also known as isobutylboronic acid. Isobutaneboronic acid has been used to synthesize potent and selective dipeptidyl boronic acid proteasome inhibitors, which are promising therapeutics to treat cancer and inflammatory diseases.¹

Reference

J. Adams, M. Behnke, S. Chen, A. A. Cruickshank, L. R. Dick, L. Grenier, J. M. Klunder, Y. Ma, L. Plamondon, R. L. Stein, Potent and selective inhibitors of the proteasome: Dipeptidyl boronic acids, Bioorganic & Medicinal Chemistry Letters, 1998, vol. 8, pp. 333-338

Chemical Properties

White to Almost white powder to crystal

Uses

suzuki reaction

Uses

2-Methylpropylboronic Acid is used in the preparation of isocoumarin analogs as inhibitors of γ-secretase cleavage. Also used in the preparation of peptide boronc acid.

Uses

(2-Methylpropyl)boronic acid can be used as:
A reactant in the preparation of 4-isobutylisoquinoline from 4-bromoisoquinoline by Suzuki-Miyaura type couple reaction.
A catalyst along with aluminum hydroxide, boric acid in the polymerization of styrene.
It can also be used as a reactant in:
Copper catalyzed cross-coupling reactions.
The synthesis of polyborylalkanes by Ir-catalyzed C-H borylation reaction.
The preparation of heterosubstituted diazaboroles and borinines.

Isobutaneboronic acid(84110-40-7)Related Product Information

• Folic acid
• Chloromethyl isopropyl carbonate
• Citric acid
• Stearic acid
• Zinc borate
• 4-Methyl-2-pentanone
• Diisobutylaluminium hydride
• Methylboronic acid
• Cyclopropylboronic acid
• Glycine
• 3-Methyl-2-butanone
• DIISOBUTYLALUMINUM CHLORIDE
• 2,2-Bis(hydroxymethyl)propionic acid
• n-Butylboronic acid
• 2,6-Lutidine
• Triisobutylaluminium
• Ethyl 2-(Chlorosulfonyl)acetate
• Isobutyryl chloride