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Methylboronic acid

Basic information Safety Supplier Related

Methylboronic acid Basic information

Product Name:
Methylboronic acid
Synonyms:
  • METHYLBORON DIHYDROXIDE
  • METHYLBORONIC ACID
  • METHANEBORONIC ACID
  • CH5BO2
  • dihydroxy-methyl-borane
  • Methylboron dihydroxide, GLC Grade
  • Methylboronic acid ,98%
  • Methylboranic acid
CAS:
13061-96-6
MF:
CH5BO2
MW:
59.86
EINECS:
629-203-8
Product Categories:
  • Piperidines ,Piperazines ,Homopiperidines
  • Alkyl
  • Substituted Boronic Acids
  • API intermediates
  • Boronic acid
  • Organoborons
  • CHIRAL CHEMICALS
Mol File:
13061-96-6.mol
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Methylboronic acid Chemical Properties

Melting point:
91-94 °C (lit.)
Boiling point:
141.7±23.0 °C(Predicted)
Density 
0.965±0.06 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
solubility 
DMSO, Water
pka
9.97±0.43(Predicted)
form 
Crystalline Powder
color 
White to off-white
Water Solubility 
Soluble in water.
Sensitive 
Hygroscopic
BRN 
1731087
InChI
InChI=1S/CH5BO2/c1-2(3)4/h3-4H,1H3
InChIKey
KTMKRRPZPWUYKK-UHFFFAOYSA-N
SMILES
CB(O)O
CAS DataBase Reference
13061-96-6(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
3-10
Hazard Note 
Irritant/Keep Cold
HazardClass 
IRRITANT
HS Code 
29319090

MSDS

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Methylboronic acid Usage And Synthesis

Chemical Properties

White to light yellow crystal powde

Uses

suzuki reaction

Uses

Methylboronic Acid is a methylated derivative of boronic acid, a building block towards various intermediates in suzuki coupling.

Uses

Methylboronic acid can be used as a reagent:

  • In the palladium-catalyzed Stille and Suzuki-Miyaura cross-couplings.
  • In the microwave-heated heterogeneous palladium (Pd)-catalytized reactions.
  • In ruthenium (Ru)-catalyzed silylation reactions
  • To prepare bis(aminotropone) titanium (Ti) catalysts for ethylene polymerizations.
  • In the enantioselective asymmetric bromoaminocyclization and bromoaminocyclization using amino-thiocarbamate catalysts.
  • To prepare common building blocks for pharmaceuticals and agrochemicals.
  • To prepare chrysin analogs by Suzuki-Miyaura coupling reactions.
  • To prepare casein kinase I inhibitors.
  • In the divergent C-H functionalizations directed by sulfonamide pharmacophores in drug discovery.
  • In the synthesis of unsymmetrical monosulfides from disulfides via copper-catalyzed coupling with boronic acids.
  • In a palladium-catalyzed coupling with enol tosylates.
  • For derivatizing many carbohydrates and biologically active compounds for GLC analysis.

Methylboronic acid Preparation Products And Raw materials

Preparation Products

Methylboronic acidSupplier

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